Results 311 to 320 of about 371,093 (352)

Toll-like Receptor 2 and Toll-like Receptor 4 Expression in Human Adrenals

Hormone and Metabolic Research, 2004
Toll-like receptors (TLRs) are key elements in the innate immune response, functioning as pattern-recognition receptors for the detection and response to endotoxins and other microbial ligands. Inflammatory cytokines play an important role in the activation of the hypothalamic-pituitary-adrenal HPA axis during inflammation and sepsis.
Bornstein, SR, Schumann, RR, Rettori, V, McCann, SM, Zacharowski, KD   +4 more
openaire   +3 more sources

Conditional signaling by Toll‐like receptor 4

The FASEB Journal, 2005
ABSTRACT Signaling through Toll‐like receptor 4 (TLR4) is thought to initiate innate and adaptive immune responses. Signaling of TLR4 is usually studied using isolated cells, which are activated by subnanomolar concentrations of lipopolysaccharide (LPS).
Gregory J, Brunn, Marlo K, Bungum, Geoffrey B, Johnson, Jeffrey L, Platt   +3 more
openaire   +2 more sources

Toll-like receptor-4 and allograft responses

Transplantation, 2004
Signaling through toll-like receptors (TLRs) is believed to be the critical first step in the activation of antigen presenting cells and the initiation of adaptive immune responses. Of these receptors, TLR-4 particularly recognizes endogenous agonists and may be important for allograft responses.
Benjamin, Samstein, Geoffrey B, Johnson, Jeffrey L, Platt   +2 more
openaire   +2 more sources

Toll-like Receptor 4 Polymorphisms and Aspergillosis

New England Journal of Medicine, 2009
However, there is another possible explana -tion for the findings that should be considered. During much of the period of the study, trans -plant recipients with febrile neutropenia that was unresponsive to antibiotics received amphotericin B. This is significant because conventional and lipid formulations of amphotericin B activate phagocytic cells by
Stuart M, Levitz, Shmuel, Shoham, John D, Cleary   +2 more
openaire   +2 more sources

Toll-like receptor 2 and Toll-like receptor 4 polymorphisms in invasive pneumococcal disease

Microbes and Infection, 2007
Toll-like receptors (TLRs) recognize distinct pathogen-associated molecular patterns and trigger anti-microbial host defense responses. Several in vitro and in vivo studies in mice indicate that TLR2 and TLR4 are involved in the defense against Streptococcus pneumoniae. Studies have revealed associations between polymorphisms in TLRs and human diseases.
Moens, L., Verhaegen, J., Pierik, M.J., Vermeire, S., de Boeck, K., Peetermans, W.E., Bossuyt, X.   +6 more
openaire   +3 more sources

Expression of Toll-like Receptor 2 and Toll-like Receptor 4 in Tuberculous Pleural Effusion

Medicinal Chemistry, 2017
Toll-like receptor-2 (TLR2) and Toll-like receptor-4 (TLR4) have been reported to play a crucial role in tuberculosis, however, little is known about their expression in tuberculous pleuritis.The goal of this work is to explore the expressions of TLR2 and TLR4 in tuberculous pleuritis and their predominant expressions on cells.Levels of soluble TLR2 ...
Yingzhong, Lin, Tingmei, Feng, Jiao, Lan, Chunxia, Chen, Zhiqiang, Qin, Yanbin, Wu, Huanzhong, Shi, Jianbo, Ye, Caizhou, Wei, Wu, Wang, Luying, Huang   +10 more
openaire   +2 more sources

Toll-Like Receptor 4

Exercise and Sport Sciences Reviews, 2006
Evidence is emerging that exercise training has anti-inflammatory effects. Our early finding that blood cultures from trained subject had a reduced responsiveness to lipopolysaccharide led to a series of studies in which we measured toll-like receptor 4--the primary signaling receptor for lipopolysaccharide.
Michael G, Flynn, Brian K, McFarlin
openaire   +2 more sources

Salivary and Plasma Levels of Toll‐Like Receptor 2 and Toll‐Like Receptor 4 in Chronic Periodontitis

Journal of Periodontology, 2011
Background: This cross‐sectional study was planned to investigate whether patients with chronic periodontitis exhibit different salivary or plasma concentrations of Toll‐like receptor (TLR) 2 and TLR4 compared to subjects who are clinically healthy.Methods: Whole saliva and plasma samples were obtained and full‐mouth clinical periodontal measurements ...
Buduneli, Nurcan, Ozcaka, Ozgun, Nalbantsoy, Ayse   +2 more
openaire   +3 more sources

Toll‐like Receptor‐2 and Toll‐like Receptor‐4 Expression on Maternal Neutrophils During Pregnancy

American Journal of Reproductive Immunology, 2010
Nitsche JF, Jiang S‐W, Brost BC. Toll‐like receptor‐2 and toll‐like receptor‐4 expression on maternal neutrophils during pregnancy. Am J Reprod Immunol 2010; 64: 427–434Problem  Toll‐like receptors (TLR) are an important part of the innate immune system and are present in a variety of human tissues.
Joshua F, Nitsche, Shi-Wen, Jiang, Brian C, Brost   +2 more
openaire   +2 more sources

Comparative fine maps of bovine toll-like receptor 4 and toll-like receptor 2 regions

Mammalian Genome, 2003
Toll-like receptors are cell-surface receptors that activate innate and adaptive immune responses. We have used a 5000-rad, whole-genome radiation hybrid panel to map Toll-like receptor 4 (TLR4) to the distal end of bovine Chromosome (Chr) 8, and Toll-like receptor 2 (TLR2) to the proximal end of bovine Chr 17.
Stephen N, White, Srinivas R, Kata, James E, Womack   +2 more
openaire   +2 more sources