Results 321 to 330 of about 371,093 (352)

Suppression of homodimerization of toll-like receptor 4 by isoliquiritigenin

Phytochemistry, 2010
Toll-like receptors (TLRs) play important inductive roles in innate immune responses for host defense against invading microbial pathogens. Activation of TLR4 by lipopolysaccharide (LPS) induces dimerization of TLR4 and, subsequently, activation of downstream signaling pathways including nuclear factor-kappa B and interferon regulatory factor 3.
Se-Jeong, Park, Hyung-Sun, Youn
openaire   +2 more sources

Is There a Role for Cardiomyocyte Toll-Like Receptor 4 in Endotoxemia?

Trends in Cardiovascular Medicine, 2005
Lipopolysaccharide (LPS) is thought to be an important molecule in myocardial depression in sepsis. Toll-like receptor 4 (TLR4), the lipopolysaccharide receptor, is known to underlie these responses. Because TLR4 is expressed on both cardiac myocytes and immune cells, it is unclear as to which cell type is responsible for myocyte depression.
Samantha A, Tavener, Paul, Kubes
openaire   +2 more sources

Biological role of Toll-like receptor-4 in the brain

Journal of Neuroimmunology, 2014
The Toll-like receptors (TLRs) are a family of microbe-sensing receptors that play a central role in the regulation of the host immune system. TLR4 has been described in the brain and seems to regulate some physiological processes, such as neurogenesis. TLR4 has also been reported to play a role during neurodegenerative disorders, including Alzheimer's
TROTTA, TERESA, PORRO, CHIARA, Calvello R, Panaro M.A.   +3 more
openaire   +3 more sources

Platelets express functional Toll-like receptor-4

Blood, 2005
AbstractProfound thrombocytopenia occurs in humans with sepsis and in mice administered lipopolysaccharide (LPS). Growing evidence indicates that platelets may contribute to these abnormalities, but whether that is a direct result of LPS activation of platelets or an indirect result of other inflammatory mechanisms remains unclear.
Graciela, Andonegui, Steven M, Kerfoot, Kelly, McNagny, Kirsten V J, Ebbert, Kamala D, Patel, Paul, Kubes   +5 more
openaire   +2 more sources

Toll-like receptor 4 – a multifunctional virus recognition receptor

Trends in Microbiology
Since the initial description of Toll receptors in Drosophila and their mammalian counterparts Toll-like receptors (TLRs), numerous fundamental and applied studies have explored their crucial role as sensors of pathogen-associated molecular patterns (PAMPs).
Gerber-Tichet, Elina, Blanchet, Fabien P., Majzoub, Karim, Kremer, Eric J.   +3 more
openaire   +2 more sources

Toll-like receptor-4 in the fish immune system

Developmental & Comparative Immunology
Toll-like receptors (TLRs) represent a critical class of protein molecules integral to nonspecific immunity (innate immunity), and serve as key mediators bridging between nonspecific and specific immune responses. As an important member of the TLR multigene family, toll-like receptor 4 (TLR4) holds particular significance due to its broad expression ...
Chunxia, Li, Xubin, Zheng, Mengna, Chang, Qinyao, Tian, Zhi, He, Ziting, Tang, Xiaojing, Chen, Xiaoying, Liu, Deying, Yang, Taiming, Yan   +9 more
openaire   +2 more sources

Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective

European Journal of Medicinal Chemistry, 2022
Guoliang Chen
exaly  

Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus

Immunity, 2018
Kevin S Cashman, Esther Zumaquero Martinez, Urko M Marigorta   +2 more
exaly  

Assembly and localization of Toll-like receptor signalling complexes

Nature Reviews Immunology, 2014
Nicholas J Gay, Monique Gangloff, Clare E Bryant   +2 more
exaly  

TOLL-like Receptor 10 Genetic Variation Is Associated with Asthma in Two Independent Samples

American Journal of Respiratory and Critical Care Medicine, 2004
David J Kwiatkowski, Donata Vercelli, Fernando D Martinez   +2 more
exaly