Results 331 to 340 of about 618,091 (376)
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Current Protocols in Immunology, 2007
AbstractThe mammalian Toll‐like receptor (TLR) family consists of 13 members, and recognizes specific patterns of microbial components, called pathogen‐associated molecular patterns (PAMPs). TLR‐dependent recognition of PAMPs leads to activation of the innate immune system, which subsequently leads to activation of antigen‐specific adaptive immunity ...
Kiyoshi, Takeda, Shizuo, Akira
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AbstractThe mammalian Toll‐like receptor (TLR) family consists of 13 members, and recognizes specific patterns of microbial components, called pathogen‐associated molecular patterns (PAMPs). TLR‐dependent recognition of PAMPs leads to activation of the innate immune system, which subsequently leads to activation of antigen‐specific adaptive immunity ...
Kiyoshi, Takeda, Shizuo, Akira
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Critical Care Medicine, 2002
The ability of a host to sense invasion by pathogenic organisms and to respond appropriately to control infection is paramount to survival. In the case of sepsis and septic shock, however, an exaggerated systemic response may, in fact, contribute to the morbidity and mortality associated with overwhelming infections.
Egil, Lien, Robin R, Ingalls
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The ability of a host to sense invasion by pathogenic organisms and to respond appropriately to control infection is paramount to survival. In the case of sepsis and septic shock, however, an exaggerated systemic response may, in fact, contribute to the morbidity and mortality associated with overwhelming infections.
Egil, Lien, Robin R, Ingalls
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Microbes and Infection, 2000
Toll-like receptors (TLRs) are a growing family of molecules involved in innate immunity. Accumulating evidence suggests that TLR molecules are involved in signalling receptor complexes which recognise components of Gram-positive and Gram-negative bacteria and mycobacteria.
M, Muzio, A, Mantovani
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Toll-like receptors (TLRs) are a growing family of molecules involved in innate immunity. Accumulating evidence suggests that TLR molecules are involved in signalling receptor complexes which recognise components of Gram-positive and Gram-negative bacteria and mycobacteria.
M, Muzio, A, Mantovani
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Journal of the European Academy of Dermatology and Venereology, 2011
AbstractToll‐like receptors are important pattern recognition receptors which have key roles in both innate and adaptive immune responses. They are strongly associated with the pathogenesis of inflammatory and autoimmune diseases. Furthermore, Toll‐like receptors have also been implicated in the pathogenesis of several skin diseases such as skin ...
Gunduz, K. +2 more
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AbstractToll‐like receptors are important pattern recognition receptors which have key roles in both innate and adaptive immune responses. They are strongly associated with the pathogenesis of inflammatory and autoimmune diseases. Furthermore, Toll‐like receptors have also been implicated in the pathogenesis of several skin diseases such as skin ...
Gunduz, K. +2 more
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Toll‐Like Receptors and Diabetes
Annals of the New York Academy of Sciences, 2008Toll‐like receptors (TLRs) recognize molecular patterns relating to a variety of microbial infections. Stimulation through TLRs leads to activation of antigen‐presenting cells, production of inflammatory cytokines creating inflammation, and production of type 1 interferons (IFNs) that include IFN‐α and ‐β, and exerts direct effects on regulatory cells.
Wong, FS, Wen, L
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Toll-like receptors and sepsis
Current Infectious Disease Reports, 2004Recent evidence suggests that Toll-like receptors (TLRs) play a major role in innate immunity to recognize specific molecular patterns derived from pathogens, including lipid, protein, DNA, and RNA, and to fight against pathogens. Each TLR displays a difference in the expression pattern, intracellular localization, and signaling pathway, resulting in ...
Ken J, Ishii, Shizuo, Akira
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Small-Molecule Modulators of Toll-like Receptors.
Accounts of Chemical Research, 2020ConspectusToll-like receptors (TLRs) are the "gatekeepers" of the immune system in humans and other animals to protect the host from invading bacteria, viruses, and other microorganisms. Since TLR4 was discovered as the receptor for endotoxin in the late
Yibo Wang +7 more
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Toll-like receptors in the spotlight
Nature Immunology, 2003Evidence that the relatively new field of Toll-like receptors (TLRs) has come of age was apparent at a meeting held by the Biochemical Society at the Novartis Respiratory Centre in Horsham, UK, on 3 February 2003. The meeting covered a wide range of topics including how the innate response is tailored to the invading pathogen, how TLRs might have ...
Luke A J, O'Neill +2 more
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Toll-like receptors and the eye
Current Opinion in Allergy and Clinical Immunology, 2005This review will describe the structure, expression/distribution and functional activity of Toll-like receptors, in particular in the ocular structures. It will also discuss innate and adaptive immune responses, by exploring the possible modulation/regulation of innate and adaptive immunity by Toll-like receptors, in view of recent findings observed in
Micera, Alessandra +4 more
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Toll-Like Receptors and Their Ligands
2002The Toll-like receptors (TLRs) are key molecules involved in the recognition of pathogens by the innate immune system. This family of germ line-encoded receptors has evolved to recognize conserved features of microbes. Currently, 10 TLR family members have been identified in mammals.
G M, Barton, R, Medzhitov
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