Results 281 to 290 of about 702,452 (359)

Comparative 3D‐anatomy of Appendicularian Endostyles (Tunicata, Chordata) ‐ A Tale of Reduction

Journal of Morphology, Volume 286, Issue 7, July 2025.
Appendicularia are chordates that possess endostyles, a pharyngeal gland homologous to vertebrate thyroid. Here, we describe the detailed 3D‐anatomy of endostyles based on light‐ and electron microscopy. We identified seven cell types arranged in specific patterns.
Mai‐Lee Van Le, Seowon Park, Thomas Stach   +2 more
wiley   +1 more source

Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy

MedComm, Volume 6, Issue 7, July 2025.
TET family proteins play a critical role in DNA demethylation, and their mutations and dysregulation contribute to the onset of multiple diseases. With a deeper understanding of the molecular mechanisms of TET involvement in disease, drug therapy targeting TET proteins shows great potential, which provides insights into new therapeutic strategies ...
Junzhi Liang, Xinni Na, Lingbo Meng, Lixia He, Ting Shu, Yuanyuan Fang, Bowen Zhang, Zhongyu Zhao, Cuishan Guo, Tingting Li, Zhijing Na, Da Li, Xue Xiao   +12 more
wiley   +1 more source

Incidence and Immunopathology of Myositis in Rectal Cancer Patients Treated With Neoadjuvant Immune Checkpoint Inhibitors and Chemoradiotherapy: Findings From the CHINOREC Trial

MedComm, Volume 6, Issue 7, July 2025.
ICI‐induced myositis occurred at a higher‐than‐expected rate (12%) in neoadjuvant‐treated rectal cancer patients receiving CRT+ICI. Elevated cTnT, but not cTnI, differentiated skeletal from cardiac involvement. Immunopathology showed a predominant CD8+ T cell infiltrate, highlighting a T cell‐mediated mechanism that necessitates early detection and ...
Rebecca Zirnbauer, Simon Hametner, Jutta Bergler‐Klein, Irene Kuehrer, Askin Kulu, Daphni Ammon, Julijan Kabiljo, Anton Stift, Rainer Schmid, Leonhard Müllauer, Clemens Bittermann, Friedrich Laengle, Klaus Machold, Stephan Blüml, Michael Bergmann, Johannes Laengle   +15 more
wiley   +1 more source

Between Two Extremes: Tripsacum dactyloides Root Anatomical Responses to Drought and Waterlogging

Plant Direct, Volume 9, Issue 7, July 2025.
ABSTRACT Plant roots are the critical interface between plants, soil, and microorganisms, and respond dynamically to changes in water availability. Although anatomical adaptations of roots to water stress (e.g., the formation of root cortical aerenchyma) are well documented, it remains unclear whether these responses manifest along the length of ...
Joel F. Swift, Desi Thimesch, Lucas Bengfort, Shahzaib Asif, Maggie R. Wagner   +4 more
wiley   +1 more source

Kartogenin‐Loaded Aminated Hollow Mesoporous Prussian Blue Nanozyme‐Reinforced Hydrogel Remodels the Senescent Microenvironment via Reactive Oxygen Species Scavenging and Stimulator of Interferon Genes Inhibition to Promote Cartilage Regeneration

Small Structures, Volume 6, Issue 7, July 2025.
This study successfully develops an injectable, dual‐function nanocomposite hydrogel comprising kartogenin‐loaded aminated hollow mesoporous Prussian blue (NH2‐HMPB) nanozyme (termed NH@K nanozyme) and hyaluronic acid methacrylate (HAMA). NH@K nanozyme rejuvenates the senescent microenvironment by scavenging reactive oxygen species and inhibiting ...
Shu‐Hang He, Zhi‐Han Shen, Ren Zhang, Po‐Lin Liu, Xu‐Ran Li, Qing‐Song Deng, Yu‐Chen Zhang, Ang Wang, Xiao‐Qiu Dou, Shang‐Chun Guo, Shi‐Cong Tao   +10 more
wiley   +1 more source

Neurodevelopmental Consequences of Maternal Diabetes: Autophagy and Spatial Arrangement of Hippocampal Neurons

CNS Neuroscience &Therapeutics, Volume 31, Issue 7, July 2025.
The study explores the impact of maternal diabetes on neonatal brain development, revealing significant weight reductions and alterations in brain structure, suggesting potential neurodevelopmental consequences and insulin treatment benefits. ABSTRACT Background Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder that disrupts fetal ...
Saleheh Mansouri Boutegaz, Mohammad Reza Namavar, Mehri Shadi, Hamid Kabiri‐rad, Saeed Vafaei‐Nezhad   +4 more
wiley   +1 more source

Lipase M Is Essential for Skin Barrier Function in Mice

Experimental Dermatology, Volume 34, Issue 7, July 2025.
ABSTRACT A functional skin barrier is essential for restricting water losses for terrestrial animals. The outermost layer of this barrier, the stratum corneum, consists of corneocytes (derived from terminally differentiated keratinocytes) coated with a protein‐rich envelope and a conjugated lipid‐rich envelope embedded in an organised hydrophobic ...
Hong‐Ming Zhou, Jinan Li, Shaohui Liu, Miguel Barriera Diaz, Qun Wang, Emma H. Doud, Whitney Smith‐Kinnaman, Derrick A. Gray, Sou Shirai, Keisuke Jojima, Akio Kihara, Bo Zhao, Matthew J. Turner   +12 more
wiley   +1 more source

The G protein‐coupled receptor GPR89A is a novel potential therapeutic target to overcome cisplatin resistance in NSCLC Calu1 cells

The FEBS Journal, Volume 292, Issue 14, Page 3755-3770, July 2025.
A genome‐wide CRISPR‐Cas9‐based genetic screen in cisplatin‐resistant NSCLC cells revealed 63 potential candidate genes for overcoming cisplatin resistance, including GPR89A. GPR89A, localised in the Golgi, modulates voltage‐gated anion channel activity and is involved in intracellular pH reduction.
Hale Guler Kara, Eda Dogan, Vildan Bozok, Cagdas Aktan, Ece Cakiroglu, Zuhal Eroglu, Duygu Aygunes Jafari, Kemal Sami Korkmaz, Serif Senturk, Buket Kosova   +9 more
wiley   +1 more source

Utility of rapid on-site evaluation (ROSE) using toluidine blue stain in respiratory cytology

Mohit Kumar, Archana Bhat, Don Gregory Mascarenhas   +2 more
openalex   +2 more sources