Results 51 to 60 of about 259,417 (265)

MicroCT reveals domesticated rice (Oryza sativa) within pottery sherds from early Neolithic sites (4150–3265 cal BP) in Southeast Asia

Scientific Reports, 2017
Rice (Oryza sativa) was domesticated in the Yangtze Valley region at least 6000–8000 years ago, yet the timing of dispersal of domesticated rice to Southeast Asia is contentious.
Aleese Barron, Michael Turner, Levi Beeching, Peter Bellwood, Philip Piper, Elle Grono, Rebecca Jones, Marc Oxenham, Nguyen Khanh Trung Kien, Tim Senden, Tim Denham   +10 more
doaj   +1 more source

X-ray induced acoustic computed tomography

Photoacoustics, 2020
X-ray imaging has proved invaluable in medical diagnoses and non-destructive testing (NDT) in the past century. However, there remain two major limitations: radiation harm and inaccessibility to the sample.
P. Samant, L. Trevisi, X. Ji, L. Xiang
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Analyses non destructives par tomographie à rayons X

Les Nouvelles de l’Archéologie, 2020
X-ray imaging techniques benefit from developments in physics, mathematics, and computer science, and provide analytical tools to study 3D internal structures of a wide range of objects.
Patricia Wils
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

X-ray computed tomography for composites

, 2014
Presentation made at the 53rd Annual Conference of the British Institute of Non-Destructive Testing at Manchester on September 10 2014.
Léonard, Fabien, Stein, Jasmin, Gresil, Matthieu, Constantinos Soutis   +3 more
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Predicting dialyzer fiber blocking is hard due to high intrapatient variability and limited utility of thrombin generation markers

Scientific Reports
To date, no reliable blood-based or instrumental parameters are available to quantify dialyzer fiber blocking during hemodialysis. The only accurate method remains micro-computed tomography (µCT) imaging of the hemodialyzer post-dialysis, a labor ...
Sunny Eloot, Tom Mertens, Iván Josipovic, Joke Konings, Griet Glorieux, Laura E. Fredenburgh, Mark Roest, Rolando Acosta, Filip De Somer, Ethan P. Marin, Matthieu N. Boone, Wim Van Biesen, Floris Vanommeslaeghe   +12 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source