Results 271 to 280 of about 3,156,249 (386)
Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov +10 morewiley +1 more sourceConsensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation.
Journal of the American College of Cardiology, 2012 G. Tearney, E. Regar, T. Akasaka, T. Adriaenssens, P. Barlis, H. Bezerra, B. Bouma, N. Bruining, Jin-man Cho, S. Chowdhary, M. Costa, R. de Silva, J. Dijkstra, C. Di Mario, D. Dudek, E. Falk, M. Feldman, P. Fitzgerald, H. Garcia-Garcia, N. Gonzalo, J. Granada, G. Guagliumi, N. Holm, Y. Honda, F. Ikeno, M. Kawasaki, J. Kochman, L. Koltowski, T. Kubo, T. Kume, Hiroyuki Kyono, C. Lam, G. Lamouche, David P. Lee, M. Leon, A. Maehara, O. Manfrini, G. Mintz, Kyiouchi Mizuno, M. Morel, S. Nadkarni, H. Okura, H. Otake, A. Pietrasik, F. Prati, L. Räber, M. Radu, J. Rieber, M. Riga, A. Rollins, M. Rosenberg, V. Sirbu, P. Serruys, K. Shimada, T. Shinke, J. Shite, E. Siegel, S. Sonoda, M. Suter, Shigeho Takarada, A. Tanaka, M. Terashima, T. Thim, S. Uemura, G. Ughi, H. V. van Beusekom, A. V. D. van der Steen, G. van Es, G. van Soest, R. Virmani, S. Waxman, N. Weissman, G. Weisz +72 moresemanticscholar +1 more sourceThe influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients
Molecular Oncology, EarlyView.This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken +8 morewiley +1 more sourceHypomethylating agents increase L1 retroelement expression without inducing novel insertions in myeloid malignancies
Molecular Oncology, EarlyView.We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.Šárka Pavlová, Hana Svozilová, Marcela Krzyžánková, Radim Sonnek, Anastasiya Volakhava, Anastasia Smirnova, Tatiana Grigoreva, Zuzana Jašková, Hana Synáčková, Dennis Wahl, Michaela Bilčíková, Libor Červinek, Šárka Pospíšilová, Ilgar Mamedov, Karla Plevová +14 morewiley +1 more sourceYAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna +9 morewiley +1 more source