Results 101 to 110 of about 492,852 (312)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Tone and intonation

open access: yes, 2015
Most of the literature on intonation derives from pioneering studies on English intonation. These authors and their followers have identified the exponents of intonation as F0, rhythm (including length and pauses) and intensity. The difficulty when studying intonation in ‘tone languages’ is that F0 is already mobilised by the lexicon and the morpho ...
openaire   +2 more sources

Information flyer of Wolfe Tone Society [PDF]

open access: yes
Flyer with information about the Wolfe Tone Society, Irish Republican Support Group, their campaigns and their areas of ...
Wolfe Tone Society, WTS   +1 more
core  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

When marking tone reduces fluency: an orthography experiment in Cameroon

open access: yes, 1999
Should an alphabetic orthography for a tone language include tone marks? Opinion and practice are divided along three lines: zero marking, phonemic marking and various reduced marking schemes.
Bird, Steven
core  

Robust dynamic tone feature extraction using 2D oriented filters

open access: yes, 2005
A novel method is proposed to extract dynamic tone features using 2D oriented filters. As 2D oriented filters are capable of capturing pitch orientations, they can make full use of the information from neighbouring frames to extract dynamic tone features
J. Cai, Cai J., Cai, Jinhai
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Dial Tone Drone

open access: yes, 2014
For Telephone, Satz focusses on the familiar pitch of the electronic dial tone, a signal of live telephonic connection which came into widespread use in 1950s.
Satz, Aura
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

SUPERSEDED - Relating production and perception of L2 tone: supplementary materials

open access: yes, 2019
## This item has been replaced by the one which can be found at https://doi.org/10.7488/ds/2635 ## This dataset contains supplementary materials to the paper "Relating the production and perception of L2 tone".
Đinh Lư Giang, Kirby, James
core   +1 more source

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