Results 131 to 140 of about 1,724,932 (347)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Voiceless Tone Depressors in Nambya and Botswana Kalang'a
, 2001 Laura J. Downing, Bryan Gick
openalex +2 more sources
Big data analytics capabilities (BDAC) and sustainability reporting on Facebook: Does tone at the top matter? [PDF]
, 2023 Fareyha Said +2 more
openalex +1 more source
Flight-Effects on Predicted Fan Fly-By Noise [PDF]
The impact on PNLT (Perceived Noise Level, Tone corrected) and Fly-by EPNL (Effective Perceived Noise Level) when forward motion reduces the noise generated by the bypass fan of an aircraft engine was studied.
Clark, B. J., Heidmann, M. F.
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Intra-Rater and Inter-Rater Reliability Analysis of Muscle-Tone Evaluation Using a Myotonometer for Children with Developmental Disabilities [PDF]
, 2023 Heeae Seo +3 more
openalex +1 more source
Acoustic Signatures of a Model Fan in the NASA-Lewis Anechoic Wind Tunnel [PDF]
One-third octave band and narrowband spectra and continuous directivity patterns radiated from an inlet are presented over ranges of fan operating conditions, tunnel velocity, and angle of attack.
Abbott, J. M. +2 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Language-to-music transfer effects depend on the tone language: Akan vs. East Asian tone languages [PDF]
, 2023 Sarah C. Creel +2 more
openalex +1 more source