Results 131 to 140 of about 1,605,291 (333)

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

open access: yesMolecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé   +7 more
wiley   +1 more source

On the r>h Shift in Kiên Giang Khmer

open access: yesJournal of the Southeast Asian Linguistics Society, 2017
This paper presents an acoustic and perceptual study of the r>h shift in the variety of Khmer spoken in Giồng Riềng district, Kiên Giang province, Vietnam. In Phnom Penh Khmer, /r/ is realized as [h] in syllable onsets and onset clusters, and accompanied
James Kirby, Đinh Lư Giang
doaj  

The Tones from Bells [PDF]

open access: green, 1920
Arthur Taber Jones
openalex   +1 more source

Boundary tones and the phonetic implementation of tone in Chichewa

open access: yesStudies in African Linguistics, 1996
In Chichewa (Bantu, Malawi), there are three differences in fundamental frequency (£0) between questions and statements: (a) questions have a fmal rise, while statements have a final fall, (b) questions do not display the strong downdrift trend found in statements, and (c) questions are produced in a higher pitch range than statements.
openaire   +4 more sources

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Antimultipath communication by injecting tone into null in signal spectrum [PDF]

open access: yes, 1987
A transmitter for digital radio communication creates a null by balanced encoding of data modulated on an RF carrier, and inserts a calibration tone within the null. This is accomplished by having the calibration tone coincide in phase and frequency with
Davarian, Faramaz
core   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

The Roles of Segments and Tone in Mandarin Lexical Processing: An ERP Study

open access: yesJournal of Integrative Neuroscience
Backgrounds: Segments and tone are important sub-syllabic units that play large roles in lexical processing in tonal languages. However, their roles in lexical processing remain unclear, and the event-related potential (ERP) technique will benefit the ...
Dan Du, Minghu Jiang
doaj   +1 more source

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