Results 111 to 120 of about 139,672 (262)

Thresholds of perception of irregular signal frequency changes

Archives of Acoustics, 2015
In the literature, the problem of the perception of signal frequency changes has been considered mainly with reference to regular changes, obtained in the process of frequency modulation of a tone by a tone.
Edward OZIMEK, Aleksander SĘK
doaj  

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Review: spinal shock, crossed extensor reflex, and mass reflex in dogs and cats-a literature review, clinical observations and considerations. [PDF]

Front Vet Sci
Santifort KM, Polidoro D, Hermans M, Olszewska A, Kaczmarska A, Poli F, Bongers J.   +6 more
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Why The Polyvagal Theory Is Untenable: An international expert evaluation of the polyvagal theory and commentary upon Porges, S.W. (2025). Polyvagal theory: current status, clinical applications, and future directions. Clin. Neuropsychiatry, 22(3), 169-184. [PDF]

Clin Neuropsychiatry
Grossman P, Ackland GL, Allen AM, Berntson GGB, Booth LC, Burghardt GM, Buron J, Dinets V, Doody JS, Dutschmann M, Farmer DGS, Fisher JP, Gourine AV, Joyner MJ, Karemaker JM, Khalsa SS, Lakatta EG, Leite CAC, Macefield VG, Machado BH, Machado RM, Menuet C, Mendelowitz D, Moraes DJA, Neuhuber W, Ottaviani MM, Paterson DJ, Paton JFP, Pellegrino PR, Ramchandra R, Shanks J, Schwaber JS, Shivkumar K, Spyer KM, Taylor EW, Taylor JA, Wang T, Yao ST, Zucker IH.   +38 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Arteriolar Collapse and Haemodynamic Incoherence in Shock: Rethinking Critical Closing Pressure. [PDF]

J Pers Med
Miller A, Rola P, Spiegel R, Haycock K.
europepmc   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Data-driven diagnosis and clinical presentation of high-tone pelvic floor dysfunction. [PDF]

Am J Obstet Gynecol
Till SR, Schrepf A, Arewasikporn A, Kratz AL, Missmer SA, As-Sanie S.   +5 more
europepmc   +1 more source