Results 171 to 180 of about 6,019,075 (368)

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

open access: yesMolecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza   +5 more
wiley   +1 more source

G-SemTMO: Tone Mapping With a Trainable Semantic Graph

open access: yesIEEE Access
A Tone Mapping Operator (TMO) is required to render images with a High Dynamic Range (HDR) on media with limited dynamic capabilities. TMOs compress the dynamic range with the aim of preserving the visually perceptual cues of the scene.
Abhishek Goswami   +5 more
doaj   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

open access: yesMolecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha   +10 more
wiley   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

open access: yesMolecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun   +5 more
wiley   +1 more source

The tone of Black Theology debates towards democratic dispensation in South Africa: 1985–1994

open access: yesVerbum et Ecclesia
The tone of the Black Theology debates took different forms depending on the relevant political processes and dispensations in which they were debated.
Mnyalaza T. Masuku
doaj   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

Thresholds of perception of irregular signal frequency changes

open access: yesArchives of Acoustics, 2015
In the literature, the problem of the perception of signal frequency changes has been considered mainly with reference to regular changes, obtained in the process of frequency modulation of a tone by a tone.
Edward OZIMEK, Aleksander SĘK
doaj  

Unraveling the effects of leader perfectionism on team dynamics: an emotion-motivation perspective

open access: yesHumanities & Social Sciences Communications
Perfectionism has gained increasing attention from researchers due to its significant impact on work and non-work outcomes. However, it remains unclear whether the influence of perfectionism on teams is positive or negative. Our research provides clarity
Yamei Liu   +3 more
doaj   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

open access: yesFEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng   +13 more
wiley   +1 more source

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