Results 61 to 70 of about 846,161 (343)

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

open access: yesFEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher   +6 more
wiley   +1 more source

On Secondary Tones Arising in Trailing-Edge Noise at Moderate Reynolds Numbers [PDF]

open access: yes, 2019
Direct numerical simulations are carried out to investigate the flow features responsible for secondary tones arising in trailing-edge noise at moderate Reynolds numbers. Simulations are performed for a NACA 0012 airfoil at freestream Mach numbers 0.1, 0.2 and 0.3 for angle of incidence 0 deg. and for Mach number 0.3 at 3 deg. angle of incidence.
arxiv   +1 more source

To B-Sharp or Not to B-Sharp: Tone Deafness in the Modern World [PDF]

open access: yes
The idea of tone deafness is commonly-referenced in both pop culture and the professional music industry. Tone deafness, or amusia, has been moderately studied as a cognitive disorder resulting from brain damage, but has rarely been examined as a ...
Zhuang, Joyce
core   +2 more sources

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

open access: yesFEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra   +7 more
wiley   +1 more source

Methods used to investigate tone of pelvic floor muscles in pelvic health conditions: A systematic review

open access: yesContinence, 2023
Aim:: This study aimed to systematically review which tools and outcome measures have been used to assess increased tone of PFM in pelvic health conditions. Methods:: Databases were searched for papers that studied increased PFM tone in any pelvic health
Rachel Worman   +3 more
doaj  

Inward Rectifier Potassium Channels: Membrane Lipid-Dependent Mechanosensitive Gates in Brain Vascular Cells

open access: yesFrontiers in Cardiovascular Medicine, 2022
Cerebral arteries contain two primary and interacting cell types, smooth muscle (SMCs) and endothelial cells (ECs), which are each capable of sensing particular hemodynamic forces to set basal tone and brain perfusion.
Maria Sancho   +3 more
doaj   +1 more source

Impact of data breaches on accounting narratives : a study on S&P 500 MED firms [PDF]

open access: yes, 2023
In light of rising cybersecurity concerns, companies are increasingly focusing on risk management and data security. This study explores the disclosure of cybersecurity incidents as a proxy for changes in financial reporting tone.
Clemente, Gonçalo Monteiro
core  

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

open access: yesFEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga   +6 more
wiley   +1 more source

The influence of directors’ and officers’ liability insurance on management tone manipulation – evidence from China

open access: yesChina Accounting and Finance Review
This paper explores the association between directors’ and officers’ liability insurance (D&O insurance) and management tone manipulation. This study uses data from A-share listed non-financial companies from 2009 to 2021 as its sample for empirical ...
Wei Xiong   +3 more
doaj   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

Home - About - Disclaimer - Privacy