Results 71 to 80 of about 139,672 (262)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Tonal Minimal Pairs in Xitsonga: A Study of Nouns and Verbs [PDF]
E-Journal of Humanities, Arts and Social SciencesThis study examined the role of tone in Xitsonga minimal pairs, focusing on nouns and verbs. Using a descriptive qualitative approach, it applied a desktop research method to analyse data from secondary sources such as published literature, dictionaries,
Respect Mlambo
doaj +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Akan tone encoding across musical modalities
Studies in African LinguisticsMusical surrogate languages like talking drums remain understudied in the linguistics literature, despite their close connection with the phonetics and phonology of the spoken language. African surrogate languages tend to be based on tone, making them a
Laura McPherson, Michael Obiri-Yeboah
doaj
Frontiers in PsychologyObjectiveThis study aims to precisely model the nonlinear relationship between university students’ literature reading preferences (LRP) and their levels of anxiety and depression using a multilayer perceptron (MLP) to identify reading-related risk ...
Yamei Liu
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Journal of Radiotherapy in PracticeAbstract Introduction: Radiotherapy is a common treatment modality for cancer patients. Unfortunately, the treatment can result in skin reactions that may affect their quality of life and clinical outcomes. PILs can provide guidance on managing early symptoms and reduce unscheduled treatment breaks.
S. Knight, S. Macwan
openaire +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
On the use of a personal or neutral tone in written feedback
Journal of Learning Development in Higher EducationIt is well-known that the emotional response upon receiving feedback can impact how learners incorporate the comments received into their future learning.
Rachel Player
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Das Inkarnat in der griechischen Malerei
RIHA Journal, 2012 Up to the present the flesh tone in painting of the classical Greek period has been only in the interest of a few archaeologists. In contrast to the approaches of these researchers, who discuss ancient painting of flesh tone by referring to medieval ...
Schmuhl, Yvonne
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