Results 151 to 160 of about 470,615 (308)

New insights into the genetic progression of cancer through longitudinal analysis of oral lesions

open access: yesThe Journal of Pathology, EarlyView.
Abstract Genetic progression models of cancer continue to determine the roadmap of carcinogenesis, although the sequence of genetic events is inferred rather than empirically determined through longitudinal analyses. Here, we present a unique longitudinal study of oral leukoplakia lesions that transformed into carcinoma.
Leon J Wils   +9 more
wiley   +1 more source

Revisionist history uncovers a simplified molecular‐based classification of differentiated thyroid cancer

open access: yesThe Journal of Pathology, EarlyView.
Abstract The diagnostic classification of differentiated thyroid cancer has been a longstanding topic of debate among pathologists, largely due to high interobserver variability. This complexity has increased with the expansion of tumor types and subtypes.
Sylvia L Asa   +8 more
wiley   +1 more source

Activation of PI3K and deletion of p53 in keratin 15‐expressing mouse mammary cells induces tumor heterogeneity and plasticity modeling metaplastic breast cancer

open access: yesThe Journal of Pathology, EarlyView.
Abstract Although relatively rare, metaplastic breast cancer responds poorly to traditional therapies compared to other subtypes. Accordingly, there is a need for novel animal models to understand its pathogenesis and plasticity. Since alterations in PIK3CA and TP53 genes are common in metaplastic breast cancer, we generated a mouse model of ...
Khoa A Nguyen   +11 more
wiley   +1 more source

Spatiotemporal Interrogation of Single Spheroids Using Multiplexed Nanoplasmonic‐Fluorescence Imaging

open access: yesSmall Methods, EarlyView.
This work introduces a multiplexed imaging platform that integrates nanoplasmonic sensing with fluorescence microscopy for concomitant monitoring of extraspheroid secretions and intraspheroid features over extended periods with spatiotemporal resolution.
Saeid Ansaryan   +7 more
wiley   +1 more source

[The value of endoscopic ultrasound examination for tongue neoplasms].

open access: yesOtolaryngologia polska = The Polish otolaryngology, 2001
The aim of the paper was to assess the value of endoral ultrasound in tongue tumors diagnostics. It was performed by the evaluation of the tumor advancement and its comparison with palpation, assessment of neoplastic tissue infiltration, detection of satellite foci surrounding the main tumor mass.
openaire   +1 more source

Spasmodic Dysphonia

open access: yesWorld Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Spasmodic dysphonia is a laryngeal dystonia that can present as adductor, abductor, or mixed types, with or without tremor. The etiology is not understood fully. Comprehensive evaluation is required to establish the diagnosis. Treatments include voice therapy, medications, botulinum toxin injection, laryngeal surgery, deep brain stimulation ...
Aaron J. Jaworek, Robert T. Sataloff
wiley   +1 more source

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