Results 261 to 270 of about 502,717 (365)

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

open access: yesThe FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou   +4 more
wiley   +1 more source

CDKN2A deletion in p16‐negative/HPV‐positive head and neck squamous cell carcinoma: Highlighting the molecular basis behind the limitation of relying on p16 immunohistochemistry as a surrogate marker for HPV involvement

open access: yesHistopathology, EarlyView.
We present a case series of HPV‐positive non‐keratinizing squamous cell carcinoma of the head and neck with discordant negative p16 staining due to CDKN2A deletion. These findings highlight the genomic basis behind the diagnostic pitfall of reliance on p16 immunohistochemistry as a surrogate marker of HPV and raise practice‐changing considerations for ...
Trevor Teich   +8 more
wiley   +1 more source

Sex Differences in Health‐Related Quality of Life in Patients With Head and Neck Cancer—A Prospective Study

open access: yesInternational Journal of Dental Hygiene, EarlyView.
ABSTRACT Objective To analyse sex differences in health‐related quality of life (HRQL) before, during and up to 3 months posttreatment of head and neck cancer, and to examine the importance of salivary secretion rate for HRQL posttreatment. Methods Patients were recruited before starting curative oncologic treatment.
Niklas Bohm   +4 more
wiley   +1 more source

Dermatologic Features of Endocrine Tumor Syndromes—Systematic Review and Meta‐Analysis

open access: yesInternational Journal of Dermatology, EarlyView.
ABSTRACT Endocrine tumor syndromes, including multiple endocrine neoplasia types 1, 2A, and 2B (MEN1, MEN2A, MEN2B), Carney complex (CNC), and PTEN hamartoma tumor syndrome (PHTS), are hereditary conditions characterized by multisystem tumor development.
Sára Pálla   +8 more
wiley   +1 more source

Current Progress of Tissue Engineering With Stem Cells in Urology Updated Review in 2025

open access: yesInternational Journal of Urology, EarlyView.
ABSTRACT Tissue engineering, a key component of regenerative medicine, aims to restore the structure and function of damaged organs using combinations of cells, scaffolds, and bioactive factors. In urology, the integration of stem cell biology has fueled significant progress in preclinical models for kidney, bladder, and urethral regeneration ...
Kenichi Kobayashi   +5 more
wiley   +1 more source

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