A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu +17 more
wiley +1 more source
Contrast-induced encephalopathy presenting with refractory status epilepticus following endovascular coiling of an intracranial aneurysm: A case report and literature review. [PDF]
Jing L, Zhao Z, Wan S, Wang M, Shao G.
europepmc +1 more source
The nanoparticle loading enables effective control over the liquid domain size in bicontinuous interfacially jammed emulsion gels (bijels) produced through solvent‐transfer induced phase separation (STrIPS). The relationship between the nanoparticle loading and domain size profiles in STrIPS bijels is resolved through confocal microscopy and explained ...
Jesse M. Steenhoff, Martin F. Haase
wiley +1 more source
Clinical applications of invasive spinal cord stimulation in neurological disorders: a narrative review. [PDF]
He M +5 more
europepmc +1 more source
A Sr‐free air electrode for high‐temperature solid oxide cells is designed by independently tailoring electronic conduction, ionic transport, and surface catalysis using complementary Sr‐free phases and infiltrated nanocatalysts. It delivers performance comparable to state‐of‐the‐art Sr‐containing electrodes while completely suppressing Cr‐induced ...
Ji‐eun Won +10 more
wiley +1 more source
Transcutaneous auricular vagus nerve stimulation and emotional responding in borderline personality disorder: a randomized single-blind, sham-controlled study. [PDF]
Guerriero G +5 more
europepmc +1 more source
Butterfly wing–inspired intrinsically self‐healing polymer interlayers enable flexible perovskite optoelectronics with high luminance, strain‐insensitive stability, and environmental resilience. These hierarchically structured films redistribute mechanical stress, suppress defect formation, and maintain performance under repeated bending, paving the ...
Loganathan Veeramuthu +13 more
wiley +1 more source
Predicting emotional valence in autism: a preregistered study in the Bayesian Brain framework. [PDF]
Plank IS +5 more
europepmc +1 more source
Chemical vapor deposition produces large‐grain, phase‐pure CsPbBr3 films (grains up to 35 µm) with Drude‐like terahertz photoconductivity and twofold higher carrier mobility versus spin‐coated references. These microstructural advances translate into photodetectors with a detectivity of 8.4 × 1012 Jones, dark current below 1 pA cm−2, X‐ray sensitivity ...
Roel Vanden Brande +14 more
wiley +1 more source
Hippocampal Astrocytes Impact Postnatal Development of Inhibitory Connections, Parvalbumin Levels, Social, and Spatial Navigation Behaviors in a Mouse Model of Fragile X Syndrome. [PDF]
Wagner VA +9 more
europepmc +1 more source

