Results 111 to 120 of about 955,139 (370)
Journal of Responsible InnovationCOVID-19 crisis reaffirmed the power of a few companies to scale up production for mRNA vaccines, which created injustice as a few nations in the developed world benefited first from available vaccines, while LMICs waited at the back of the queue ...
Katerina Sideri
doaj +1 more source
Robust and Efficient Harmonics Denoising in Large Dataset Based on Random SVD and Soft Thresholding
IEEE Access, 2019 The Hankel matrix of harmonic signals has the important low-rank property, based on which the principal components (or the eigenvectors) extracted from the matrix by singular value decomposition (SVD) could be applied for harmonic signal denoising ...
Yu Yang, Jian Rao
doaj +1 more source
Does banks size distort market prices? Evidence for too-big-to-fail in the CDS market [PDF]
This paper examines the potential distortion of prices in the CDS market caused by too-big-to-fail. Overall, we find evidence for market discipline in the CDS market.
Völz, Manja, Wedow, Michael
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Too big to fail : origins, consequences, and outlook [PDF]
The policy of too big to fail arose in part from pressures created by the lack of satisfactory bankruptcy arrangements for banks. It prevented market forces from closing banks and protected all uninsured depositors of large banks from loss in the event ...
Robert L. Hetzel
core
Have commodity trading houses become "too big to fail" ? [PDF]
, 2016 Commodity trading is very important on a global scale, because of the nature of its activity - moving raw material from a place where it is abundant to a place where it is needed.
Lopez, Anas, Piller, Robert
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
G20: dealing with too-big-to-fail banks, corporate tax avoidance, and development [PDF]
Overview: This issue of the G20 Monitor addresses the ‘too big to fail’ dilemma of major financial institutions, combating tax evasion and avoidance through ‘base erosion and profit shifting’ (BEPS), and a report from the ‘G20 and Development’ conference
Daniela Strube +2 more
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source