Results 141 to 150 of about 955,139 (370)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Bank risk of failure and the too-big-to-fail policy [PDF]
Banks and ...
H.S. Malek, Huberto M. Ennis
core
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
How Much Did Banks Pay to Become Too-Big-To-Fail and to Become Systemically Important?
, 2011 Elijah Brewer, Julapa Jagtiani
openalex +1 more source
In Too-Big-To-Fail We Trust: Ethics and Banking in the Era of COVID-19
, 2020 Nizan Geslevich Packin
openalex +1 more source
"Observations on the Problem of 'Too Big to Fail/Save/Resolve'" [PDF]
Past experience suggests that multifunctional banking is the leading source of financial crisis, while large bank size contributes to contagion and systemic risk.
Jan Kregel
core
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Too Big to Fail: A Misguided Policy in Times of Financial Turmoil [PDF]
The bailouts carried out by governments for large banks and other financial entities in the recent financial turbulence are often characterized as a Too-Big-To-Fail (TBTF) policy.
Clyde Goodlet
core
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Academic medical centers: too big to fail. [PDF]
Clin Transl Sci, 2013 Feldman AM, DiSesa VJ, Kaiser LR.
europepmc +1 more source