Results 61 to 70 of about 903,926 (343)

Social context prevents heat hormetic effects against mutagens during fish development

open access: yesFEBS Letters, EarlyView.
This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere   +5 more
wiley   +1 more source

Mind the Gap: Is the Too Big to Fail Problem Resolved? [PDF]

open access: yesAstrophysical Journal, 2019
The faintness of satellite systems in galaxy groups has contributed to the widely discussed “missing satellite” and “too big to fail” issues. Using techniques based on Tremaine & Richstone, we show that there is no problem with the luminosity function ...
J. Ostriker   +3 more
semanticscholar   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

‘Everything is data’: towards one big data ecosystem using multiple sources of data on higher education in Indonesia

open access: yesJournal of Big Data, 2022
Big data is increasingly being promoted as a game changer for the future of science, as the volume of data has exploded in recent years. Big data characterized, among others, the data comes from multiple sources, multi-format, comply to 5-V’s in nature ...
Ariana Yunita   +2 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

Too Big to Fail? [PDF]

open access: yes, 2023
The recent sudden collapse of the Silicon Valley Bank (SVB) in the United States and the 1loss of $165 billion to the six leading Wall Street banks2 share sales and squeezed profits came as a surprise to those who believed that the ghosts of the banking ...
Reynolds, M., Reynolds, M.
core  

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

Corporate qualitative and quantitative assessment

open access: yesAudit Financiar, 2016
Until a few decades ago, the decision power to deny or grant a loan laid in the hands of a single individual: the credit analyst. Some of the bad experiences of banks losses or even failures were attributed to bad decisions made by credit analysts, who ...
Maria – Monica Haralambie   +1 more
doaj   +1 more source

Structural biases in prudential regulation of banks

open access: yesPSL Quarterly Review, 2012
According to Mario Tonveronachi, the Basle rules produce distortions that are no less serious than those attributed to the former structural regulation.
Mario Tonveronachi
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

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