Results 111 to 120 of about 5,379,499 (310)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Tool Wear in Milling of Medical Grade Cobalt Chromium Alloy - Requirements for Advanced Process Monitoring and Data Analytics

open access: yes, 2016
The Machine Tool Technologies Research Foundation (MTTRF) and iAM-CNC Annual Meeting 2016, San Fransisco, California, USA, 5-7 July 2016Computer Aided Design (CAD), Computer Aided Manufacturing (CAM) and Computer Numerical Control (CNC) are platform ...
Ahearne, Eamonn   +4 more
core  

The Advanced BioTRIZ Method Based on LTE and MPV

open access: yesBiomimetics
While BioTRIZ is widely employed in biomimetic design to facilitate creative ideation and standardize workflows, accurately formulating domain conflicts and assessing design schemes during critical stages—such as initial concept development and scheme ...
Zhonghang Bai   +3 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Demo data collection tool for ODK training

open access: yes, 2019
The demo tool for ODK data collection training was based on the Module A of the CLCA-II project data collection tool.
Bikara, Innocent
core  

Modelling flan wear of carbide tool insert in metal cutting

open access: yes, 2005
In this paper theoretical and experimental studies are carried out to investigate the intrinsic relationship between tool flank wear and operational conditions in metal cutting processes using carbide cutting inserts.Anewflank wear rate model, which ...
Liu, X   +7 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Thermal performance enhancement in a solar air heater fitted with flapped V-baffles: Numerical study

open access: yesCase Studies in Thermal Engineering
Considering solar energy equipment, a solar air heater is an engineering equipment that is widely used today. To get the most benefit from energy use, thermal performance enhancement of the equipment is very important.
Chinnapat Turakarn   +2 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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