Results 171 to 180 of about 5,379,499 (310)

Application of the Wigner distribution to monitoring cutting tool condition [PDF]

This thesis is about the application of the Wigner distribution to cutting tool monitoring and control. After reviewing traditional methods, a new method is proposed.
Zheng, Kougen
core  

Refining MediQuit: an iterative, participatory approach to shared decision-making in deprescribing. [PDF]

Implement Sci Commun
Kornder N, Burkhardt S, Hierasimowicz K, Viniol A, Donner-Banzhoff N.   +4 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Impact of reader experience on the time-saving potential of a novel computer-aided tool for Ann Arbor staging of pediatric hodgkin lymphoma. [PDF]

Front Nucl Med
Vasyliv I, Barrow MJ, Baratto L, Kim HG, von Krüchten VR, Lokesha YU, Sarrami AH, Moeremans M, Guja KE, Hawk KE, Daldrup-Link HE.   +10 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Effect of Material Microstructures on Tool Edge Preparation of PCBN Cutting Tools. [PDF]

Micromachines (Basel)
Huang Z, Wu X, Zhang C, Zhai Y.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Data collection tool for stakeholders’ mapping (AR)

This research tool is a stakeholder matrix based on pre-defined outreach queries aimed at performing the stakeholder mapping that will feed into the social network analysis.
Ouerghemmi, Hassen
core   +1 more source

Preliminary feedback from adult oncology clinic providers on a psychosocial screening tool for young adult patients with cancer. [PDF]

Support Care Cancer
Wrucke MW, Rickey G, Shi M, Shear DZ, Taghavi SE, Cantu V.   +5 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source