Results 201 to 210 of about 10,706,028 (311)

A Heart Rate Variability-Derived Decision Support Tool for Prognostication in Emergency Department Patients With Suspected Infection. [PDF]

Biomed Res Int
Seely AJE, Barnaby DP, Hudek N, Herry CL, Scales NB, Fernando SM, Brehaut JC, Perry JJ, Fallahzadeh A.   +8 more
europepmc   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Development of a multimedia informed consent tool for fixed prosthodontic treatment: A cognitive theory-based approach to enhance patient understanding. [PDF]

PEC Innov
Ndagire B, Naidoo S, Barugahare J, Balikuddembe JK, Nankabirwa J, Nakiggudde A, Mugerwa J, Wandera M, Rwenyonyi CM.   +8 more
europepmc   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Robust RP-HPLC method for the parallel determination of quaternary mixture in cold and cough syrups with sustainability appraisal. [PDF]

Sci Rep
Al-Senani GM, Al-Qahtani SD, Mahgoub SM, Ahmed HA, Mohamed MA.   +4 more
europepmc   +1 more source

Territorial observatories: a tool for development ? [PDF]

, 2017
Bonnal, Vincent, Cattan, Philippe, Jannoyer, Magalie, Le Bail, Marianne, Lemoisson, Philippe, Maurel, Pierre, Tonneau, Jean-Philippe   +6 more
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Expanding the Digital, Donor-Assisted Conception Tool to Empower Parental Telling and Talking (TELL Tool) Intervention to the Pregnant and Early Parenthood Periods: Findings From a Qualitative Study. [PDF]

JMIR Form Res
Hershberger PE, Adlam K, Richardson MB, Miller AL, Fortin C, Driessnack M, Grotevant HD, Klock SC, Pasch LA, Gallo AM.   +9 more
europepmc   +1 more source

e-Infrastructure: tool for the elite or tool for everybody? UK e-Science Technical Report Series [PDF]

, 2009
Chue Hong, Neil, Fraser, Mike, Hardisty, Alex, Hughes, Lorna, Proctor, Rob, Voss, Alex   +5 more
core