Results 241 to 250 of about 226,170 (300)

IKKβ and USP28 Regulate HEY1 Stability to Promote Cancer Stemness and Immune Evasion in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao, Lin Zhang, Gufang Shen, Yangfan Lv, Tianshu Fang, Ya Cao, Qiongyi Zhang, Feng Xu, Chungang Liu   +8 more
wiley   +1 more source

Risk of Bias Assessment of Randomized Controlled Trials: From the 1994 Cochrane Collaboration Toolkit to ROBUST-RCT. [PDF]

J Eval Clin Pract
Pacheco RL, Riera R.
europepmc   +1 more source

Integration of large vision language models for efficient post-disaster damage assessment and reporting. [PDF]

Nat Commun
Chen Z, Asadi Shamsabadi E, Jiang S, Shen L, Dias-da-Costa D.   +4 more
europepmc   +1 more source

The Six R's of Management Reasoning for Subintern Education. [PDF]

Clin Teach
Maldonado M, Boedeker P, Kusnoor AV.
europepmc   +1 more source

REVISE Virtual Reality Intervention to Prevent Sexual Harassment in Heterosexual Couples: Protocol for a Randomized Controlled Trial. [PDF]

JMIR Res Protoc
Saavedra-Roa A, Vallejo-Medina P, Seinfeld S, Bourdin-Kreitz P, Guillén-Riquelme A, Marsa-Sambola F, Medina JC, Pineda-Marin C, Paz C, Angulo-Brunet A, Montesano A.   +10 more
europepmc   +1 more source

Joint Optimization of Trajectory-Resource Allocation and Deep Task Partial Offloading for MEC-Enabled Multi-UAV. [PDF]

Sensors (Basel)
Liu C, Wang Y, Mei H, Du S, Guo B.
europepmc   +1 more source

The Flourishing Child: Study Protocol for an Acceptability and Feasibility Trial of a Digital Early Childhood Flourishing Intervention. [PDF]

Children (Basel)
Talati Z, Kennare J, Bear NL, Gibson LY, Power R, Kruger VZ, Silva D, Prescott SL, Davis JA.   +8 more
europepmc   +1 more source