Results 111 to 120 of about 7,714,818 (301)

An experience of introducing last planner into a UK construction project [PDF]

, 2003
The Last Planner methodology developed by the Lean Construction Institute is a production control tool which has possible benefits for improving planning in the UK construction industry. Its application has been considered in countries outside the UK but
Johansen, Eric, Porter, Geoff
core  

Using Indexed and Synchronous Events to Model and Validate Cyber-Physical Systems

, 2015
Timed Transition Models (TTMs) are event-based descriptions for modelling, specifying, and verifying discrete real-time systems. An event can be spontaneous, fair, or timed with specified bounds.
Hudon, Simon, Ostroff, Jonathan S., Wang, Chen-Wei   +2 more
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

The Third Party Transfer Program: A Tool Buffalo Can Use to Reduce Property Abandonment [PDF]

, 2008
Buffalo needs an effective program to quickly fight abandonment. In the past twenty years, Buffalo’s tax-foreclosure abandonment rate has increased.
Michaels, Douglas
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Ecological correlates of chimpanzee termite fishing behavior in Mbam & Djerem National Park, Cameroon

Ecology and Evolution
Chimpanzee insectivory is seasonally variable, with pronounced peaks or set seasonal periods of consumption observed in most chimpanzee communities. This variation is interesting given that chimpanzees invest considerable effort into complex tool‐using ...
Tyler C. Andres‐Bray, Jeffrey Smith, Ian Nichols, Ekwoge E. Abwe, Mary Katherine Gonder   +4 more
doaj   +1 more source

Cultural transmission of animal tool use driven by trade-offs: insights from sponge-using dolphins

Royal Society Open Science
Although tool use offers obvious benefits to the user, the role of costs in the spread of tool use has received scant attention. Sponge tool use is a foraging technique restricted to a small subpopulation of bottlenose dolphins (Tursiops aduncus) in ...
Ellen Jacobs, Chong Wei, Christine Erbe, Janet Mann   +3 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source