Results 191 to 200 of about 7,714,818 (301)

Social tolerance and role model diversity increase tool use learning opportunities across chimpanzee ontogeny. [PDF]

Commun Biol
Nodé-Langlois O, Rolland E, Girard-Buttoz C, Samuni L, Ferrari PF, Wittig RM, Crockford C.   +6 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Characterization of Stone Tool Use in Wild Groups of Critically Endangered Yellow-Breasted Capuchin Monkeys (Sapajus xanthosternos). [PDF]

Am J Biol Anthropol
Mainette RD, Lynch JW, Izar P, Canale G, Martins WP.   +4 more
europepmc   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Nonadjacent dependencies and sequential structure of chimpanzee action during a natural tool-use task. [PDF]

PeerJ
Howard-Spink E, Hayashi M, Matsuzawa T, Schofield D, Gruber T, Biro D.   +5 more
europepmc   +1 more source

Design and implementation of an Internet-Based cancer risk assessment tool: Use over 10 years. [PDF]

Cancer Med, 2023
LaRiviere MJ, O'Keefe R, Carpenter M, Chao HH, Amaniera I, Vachani C, Hampshire MK, Bach C, Arnold-Korzeniowski K, Metz JM, Hill-Kayser C.   +10 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Children's limited tooling ability in a novel concurrent tool use task supports the innovation gap. [PDF]

Sci Rep
Colbourne JAD, Auersperg AMI, Beck SR.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Generative AI tool use enhances academic achievement in sustainable education through shared metacognition and cognitive offloading among preservice teachers. [PDF]

Sci Rep
Iqbal J, Hashmi ZF, Asghar MZ, Abid MN.
europepmc   +1 more source