Results 41 to 50 of about 548,608 (363)

Tumor‐agnostic detection of circulating tumor DNA in patients with advanced pancreatic cancer using targeted DNA methylation sequencing and cell‐free DNA fragmentomics

open access: yesMolecular Oncology, EarlyView.
We evaluated circulating tumor DNA (ctDNA) detection in advanced pancreatic cancer using DNA methylation, cell‐free DNA fragment lengths, and 5′ end motifs. Machine learning models were trained to estimate ctDNA levels from each feature and their combination.
Morten Lapin   +10 more
wiley   +1 more source

Analysis of Tool Wear in GH4169 Material Milling Process

open access: yesLubricants, 2023
Nickel-based superalloy GH4169 is a material with strong mechanical properties and is difficult to process. In order to reduce tool wear during material processing and improve the workpiece surface processing quality, based on the finite element ...
Xueguang Li   +3 more
doaj   +1 more source

Hard turning with variable micro-geometry PcBN tools [PDF]

open access: yes, 2008
Cataloged from PDF version of article.This paper presents investigations on hard turning with variable edge design PcBN inserts. Turning of hardened AISI 4340 steel with uniform and variable edge design PcBN inserts is conducted, forces and tool wear ...
Karpat, Y., Ozel, T., Srivastava, A.
core   +1 more source

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach   +11 more
wiley   +1 more source

Effect of Cutting Parameters on Tool Chipping Mechanism and Tool Wear Multi-Patterns in Face Milling Inconel 718

open access: yesLubricants, 2022
Tool wear behavior is mainly influenced by cutting parameters for a given tool–workpiece pair and cutting process. Rapid tool wear increases production costs and deteriorates machining quality in manufacturing industries.
Delin Liu, Zhanqiang Liu, Bing Wang
doaj   +1 more source

Continuous Monitoring of Bladder Dysfunction in People With Multiple Sclerosis: Wearables for the Bladder

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Bladder dysfunction affects over 85% of people with multiple sclerosis (PwMS), yet current assessment methods are limited to periodic in‐clinic evaluations or subjective patient reports, failing to capture real‐world symptom fluctuations.
Valerie J. Block   +8 more
wiley   +1 more source

An Influence of Parameters of Micro-electrical Discharge Machining on Wear of Tool Electrode

open access: yesArchive of Mechanical Engineering, 2017
To achieve better precision of features generated using the micro-electrical discharge machining (micro-EDM), there is a necessity to minimize the wear of the tool electrode, because a change in the dimensions of the electrode is reflected directly or ...
Puthumana Govindan
doaj   +1 more source

Multi-Step-Ahead Tool State Monitoring Using Clustering Feature-Based Recurrent Fuzzy Neural Networks

open access: yesIEEE Access, 2021
Reliable and precise multi-step-ahead tool wear state prediction is significant to modern industries for maintaining part quality and reducing cost. This study proposes a Clustering Feature-based Recurrent Fuzzy Neural Network (CFRFNN) for tool wear ...
Jiachen Yao, Baochun Lu, Junli Zhang
doaj   +1 more source

Optimization and analysis of cutting parameters using cryogenic media in machining of high strength alloy steel [PDF]

open access: yes, 2013
In this research, liquid Argon is used as a cryogenic media to optimize the cutting parameters for evaluation of tool flank wear width of Tungsten Carbide Insert (CNMG 120404-WF 4215) while turning high strength alloy steel.
Ali, Liaqat   +5 more
core  

Investigation of a scale-up manufacturing approach for nanostructures by using a nanoscale multi-tip diamond tool [PDF]

open access: yes, 2015
Increasing interest in commercializing functional nanostructured devices heightens the need for cost-effective manufacturing approaches for nanostructures.
Jiang, Xiangqian   +4 more
core   +1 more source

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