Results 101 to 110 of about 9,214,925 (306)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
, 2012 Methodological approaches for comparing metabolic theory predictions to empirical data fall into two general categories: 1) determining if the general functional form of a relationship predicted by the theory is valid; and 2) determining whether the observed values of the parameters match the specific quantitative predictions made by the theory.
White, Ethan P. +3 more
openaire +2 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Influence of the Substrate Size on the Cooling Behavior and Properties of the DED-LB Process
Journal of Machine EngineeringThe laser-based Directed Energy Deposition (DED-LB) process involves a complex thermal history which strongly de-pends on the geometry of the deposited structure and substrate.
Fabian Bieg +2 more
doaj +1 more source
Data-Driven Teaching: Tools and Trends [PDF]
, 2006 Data-Driven Teaching: Tools and Trends, a policy brief released by the Rennie Center for Education Research and Policy, focuses on three district-based data analysis programs and highlights the policy and practice challenges associated with their use ...
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Topics in Cognitive ScienceAbstractMany core human activities require an understanding of time. To coordinate rituals, plan harvests and hunts, recall histories, keep appointments, and follow recipes, we need to grapple with invisible temporal structures like durations, sequences, and cycles. No other species seems to do this.
openaire +2 more sources
Multimedia Markup Tools for OpenKnowledge
, 2007 OpenKnowledge is a peer-to-peer system for sharing knowledge and is driven by interaction models that give the necessary context for mapping of ontological knowledge fragments necessary for the interaction to take place.
Croitoru, Madalina +6 more
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