Results 61 to 70 of about 790,952 (308)

Acoustic tooth cleaner [PDF]

, 1982
An acoustic oral hygiene unit is described that uses acoustic energy to oscillate mild abrasive particles in a water suspension which is then directed in a low pressure stream onto the teeth.
Heyman, J. S.
core   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Snhg18 regulates Yap subcellular localization to maintain bone homeostasis

Nature Communications
Osteoporosis treatments commonly mitigate bone loss but rarely restore lost bone mass. Yes-associated protein (Yap) nuclear translocation is crucial for the osteogenic differentiation of bone marrow stromal cells (BMSCs), but is disrupted by many factors
Jie Huang, Yuteng Weng, Yanhuizhi Feng, Di Wu, Yongliang Chen, Zeyuan Li, Xue Jiang, Haicheng Wang, Zuolin Wang   +8 more
doaj   +1 more source

Alterations of oral microbiota distinguish children with autism spectrum disorders from healthy controls

Scientific Reports, 2018
Altered gut microbiota is associated with autism spectrum disorders (ASD), a group of complex, fast growing but difficult-to-diagnose neurodevelopmental disorders worldwide. However, the role of the oral microbiota in ASD remains unexplored.
Yanan Qiao, Mingtao Wu, Yanhuizhi Feng, Zhichong Zhou, Lei Chen, Fengshan Chen   +5 more
doaj   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Zfp260 choreographs the early stage osteo-lineage commitment of skeletal stem cells

Nature Communications
The initial fine-tuning processes are crucial for successful bone regeneration, as they guide skeletal stem cells through progenitor differentiation toward osteo- or chondrogenic fate.
Yuteng Weng, Yanhuizhi Feng, Zeyuan Li, Shuyu Xu, Di Wu, Jie Huang, Haicheng Wang, Zuolin Wang   +7 more
doaj   +1 more source

SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway

Cellular & Molecular Biology Letters, 2017
Background Exploring the molecular mechanisms underlying directed differentiation is helpful in the development of clinical applications of mesenchymal stem cells (MSCs).
Luyuan Jin, Yu Cao, Guoxia Yu, Jinsong Wang, Xiao Lin, Lihua Ge, Juan Du, Liping Wang, Shu Diao, Xiaomeng Lian, Songlin Wang, Rui Dong, Zhaochen Shan   +12 more
doaj   +1 more source

Mesiodens preventing eruption of a permanent central incisor [PDF]

, 2005
A maxillary midline supernumerary tooth is the most common type of supernumerary tooth. We present a case of a mesiodens, preventing eruption of a permanent central incisor.
Azzopardi, Alexander, Camilleri, Simon, DePasquale, Sandra   +2 more
core  

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Sirt6 loss activates Got1 and facilitates cleft palate through abnormal activating glycolysis

Cell Death and Disease
Cleft palate (CP) is a common congenital craniofacial malformation, which is caused by a combination of genetic and environmental factors. However, its underlying mechanism has not been elucidated.
Xiaotong Wang, Xige Zhao, Xiaoyu Zheng, Xia Peng, Jing Chen, Yijia Wang, Zhiwei Wang, Mingyue Meng, Juan Du   +8 more
doaj   +1 more source