Results 31 to 40 of about 23,694,863 (285)

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

A Semi-Analytical Load Distribution Model for Cycloid Drives with Tooth Profile and Longitudinal Modifications

Applied Sciences, 2020
The current load distribution model for cycloid drives based on the Hertz contact stiffness typically assumes a two-dimensional planar problem without considering the tooth longitudinal modification effects, which fails to comply with the practical ...
Ting Zhang, Xuan Li, Yawen Wang, Lining Sun   +3 more
doaj   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Computerized generation and simulation of meshing of a novel crown gear coupling avoiding edge contact

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2019
To avoid the occurrence of the hub tooth tip edge contact with the sleeve tooth root flank and the sleeve tooth tip edge contact with the hub tooth root flank, a novel crown gear coupling composed of a hub with profile crowning, longitude crowning, and ...
Yabin GUAN, Xiaohui YANG, Zongde FANG
doaj   +1 more source

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Tooth Surface Contact Analysis of the Face Gear Pair Involving the Worm Wheel Installation Error

Jixie chuandong, 2016
The actual tooth surface equation is established considering the worm wheel installation errors based on a five- axis linked CNC grinding machine. The tooth contact analysis（ TCA analysis） on the actual tooth surface of face gear and pinion tooth surface
Cui Wei, Tang Jinyuan, Zhou Zhenyu
doaj  

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, EarlyView.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source

A study on loaded tooth contact analysis of a cycloid planetary gear reducer considering friction and bearing roller stiffness

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2017
The cycloid planetary gear drives designed in the so-called RV-type play an important role in precision power transmission. Not only the high reduction ratio, but also the shock absorbability is the significant advantage.
Ching-Hao HUANG, Shyi-Jeng TSAI
doaj   +1 more source

Accuracy Control of Hourglass Worm Gearing. Analysis of Tooth Shape and Tooth Contact.

TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series C, 1998
Feeding under-cutting of Lorentz wheel cutting method of Hindley hourglass worm gearing is analyzed at first. And the shape of the wheel tooth surface is made clear by the analysis and the measuring method of the wheel by 3-dimensional coordinate measuring machine is proposed. Statical and dynamical tooth contact are analyzed to control the accuracy of
XIN, Ji Sheng, OKAMOTO, Kazuhiko, MAKI, Minoru   +2 more
openaire   +2 more sources

A Soft Robotic Finger With Deep Learning‐Enhanced Tactile Sensing for Texture and Softness Recognition

Advanced Intelligent Systems, EarlyView.
Inspired by human touch, a tendon‐driven soft robotic finger combines multimodal tactile sensing and deep learning to simultaneously perceive texture and softness on deformable surfaces. A CNN‐LSTM model fuses pressure, accelerometer, and gyroscope signals to accurately classify material properties, achieving up to 95.4% texture and 97.0% softness ...
Gorkem Anil Al, Arya Shabani, Nicos Hadjigeorgiou, James Fant‐Male   +3 more
wiley   +1 more source