Results 21 to 30 of about 20,860 (212)

CRP Deficiency Rescues Periodontitis‐Induced Hippocampal Neurogenesis Impairment by Suppressing OPC‐Derived BMP4 Signaling in Rats

Advanced Science, EarlyView.
Chronic periodontitis elevates circulating CRP, which enters the hippocampus to upregulate BMP4 in oligodendrocyte precursor cells (OPCs), thereby impairing neurogenesis and inducing anxiety/depression‐like behaviors in rats. Counteracting this pathway, CRP deficiency helps confer functional resilience to OPCs.
Lingjie Li, Ping Deng, Siyu Hou, Xianbo Xia, Wei Zhao, Xingyu Zhu, Yang Zhang, Chao Wang, Ling Xu, Jinlin Song   +9 more
wiley   +1 more source

Multi‐Enzyme Mimetic Molybdenum Nitride Nanozymes Reshape Subgingival Microenvironment for Synergistic Periodontitis Therapy via ROS Regulation and Microbiome Remodeling

Advanced Science, EarlyView.
ABSTRACT Periodontitis, a chronic inflammatory disease initiated and sustained by plaque microorganisms and host immune response, remains an intractable oral disease and a leading cause of tooth loss worldwide. Traditional mechanical debridement and adjunctive antibiotic or antiseptic therapy often shows limited efficacy due to the complex anatomical ...
Weiyu Zhang, Zhongwei Yang, Yunfan Zhang, Longwei Wang, Xiaoyu Zhang, Jiahui Mao, Yizhi Dai, Yifan Yuan, Mingge Wang, Xin Yang, Xin Yu, Jing Liu, Chunying Chen   +12 more
wiley   +1 more source

Minimally invasive orthodontics: elastodontic therapy in a growing patient affected by Dentinogenesis Imperfecta [PDF]

, 2017
AIM: The aim of the study was to report the use of an elastodontic therapy in a growing patient affected by Dentinogenesis Imperfecta, second class malocclusion, deep bite and lower arch crowding from the deciduous dentition to permanent one. CASE
IERARDO, GAETANO, LUZZI, Valeria, NARDACCI, GIULIANA, POLIMENI, Antonella, VOZZA, Iole   +4 more
core   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Enamel fracture in the primary dentition has no impact on children's quality of life: implications for clinicians and researchers [PDF]

, 2016
Aim The aim of this study was to quantify the impact of traumatic dental injuries (TDI) on oral-health-related quality of life (OHRQoL) of preschool children, when enamel fractures were either included or excluded within the category of TDI. Material and
Abanto, Abanto, Abanto, Aldrigui, Aldrigui, Bratthal, Chadwick, Feldens, Foster, Glantz, Glendor, Gomes, Grabowski, Guedes, Guyatt, Güngör, Hasan, Kramer, Kramer, Kramer, Malmgren, Oliveira, Pahel, Petersen, Porritt, Porritt, Ramos-Jorge, Scarpelli, Terwee, Tesch, Viegas, Viegas, World Health Organization   +32 more
core   +1 more source

An Implanted Tooth That Can Feel

Advanced Science, EarlyView.
To endow the implanted tooth with masticatory perception, herein we demonstrate that a 3D‐printed piezoelectric‐core/robust‐sheath implanted tooth can rebuild the sensing feedback, serving as “mechanoreceptors” in converting the mechanical chewing force to electrical signals, and up to brain through surrounding alveolar nerve system.
Yaru Cao, Zhenhua Wu, Jiwei Sun, Ke Song, Jiayi Li, Yujin Li, Wenqi Chen, Hanyu Li, Shue Li, Cheng Yang, Silin Liu, Yunyun Han, Bin Su, Yumei Ding   +13 more
wiley   +1 more source

A Statistical Modeling Approach to Computer-Aided Quantification of Dental Biofilm [PDF]

, 2014
Biofilm is a formation of microbial material on tooth substrata. Several methods to quantify dental biofilm coverage have recently been reported in the literature, but at best they provide a semi-automated approach to quantification with significant ...
Mansoor, Awais, Patsekin, Valery, Rajwa, Bartlomiej, Robinson, J. Paul, Scherl, Dale   +4 more
core   +1 more source

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source

Construction of a MOF‐Based Snap‐Top Delivery Nanosystem for Powerful Dual‐Responsive Synergistic Colitis Treatment

Advanced Science, EarlyView.
A snap‐top delivery nanosystem based on an azobenzene metal–organic framework achieves targeted release of 6‐mercaptopurine via acid‐stable frameworks and hypoxia/pH dual‐responsive β‐cyclodextrin gates. This multifunctional platform integrates three synergistic mechanisms: precision drug delivery to inflammatory sites, intrinsic antioxidant properties
Xin Li, Miao Xu, Heran Li, Huan Jiang, Xin Wang, Lianjun Ma, Ying‐Wei Yang   +6 more
wiley   +1 more source

Clindamycin-modified Triple Antibiotic Nanofibers: A Stain-free Antimicrobial Intracanal Drug Delivery System [PDF]

, 2018
INTRODUCTION: A biocompatible strategy to promote bacterial eradication within the root canal system after pulpal necrosis of immature permanent teeth is critical to the success of regenerative endodontic procedures.
Bottino, Marco C., Feitosa, Sabrina A., Gregory, Richard L., Hamer, Ethan I., Karczewski, Ashley, Pankajakshan, Divya, Spolnik, Kenneth J.   +6 more
core   +1 more source