Results 101 to 110 of about 9,852,555 (389)

Conditioned Medium Derived From Human Dental Follicle Mesenchymal Stem Cells Alleviates Macrophage Proinflammatory Responses Through MAPK-ERK-EGR1 Axis

Stem Cells International
The regulation of macrophage polarization by mesenchymal stem cells (MSCs) is a prominent area of research but faces challenges due to limited MSC sources and incomplete understanding of underlying mechanisms.
Chuhan Zhang, Peiyi Lv, Qiuying Liang, Jian Zhou, Buling Wu, Wenan Xu   +5 more
doaj   +1 more source

Early Onset Charcot-Marie-Tooth Disease

Pediatric Neurology Briefs, 2005
The clinical signs and genetic analysis of early-onset Charcot-Marie-Tooth disease (CMT) in a 2-year-old boy and members of his family are reported from the Academic Medical Center, Amsterdam, and Sophia Children’s Hospital, Rotterdam, the Netherlands.
J Gordon Millichap
doaj   +1 more source

ALS5/SPG11/ KIAA1840 mutations cause autosomal recessive axonal Charcot–Marie–Tooth disease

Brain : a journal of neurology, 2015
Mutations in the ALS5/SPG11/ KIAA1840 gene cause autosomal recessive hereditary spastic paraplegia or autosomal recessive juvenile amyotrophic lateral sclerosis. Montecchiani et al .
C. Montecchiani, L. Pedace, Temistocle Lo Giudice, Antonella Casella, Marzia Mearini, F. Gaudiello, J. Pedroso, C. Terracciano, C. Caltagirone, R. Massa, P. S. St George-Hyslop, O. Barsottini, T. Kawarai, A. Orlacchio   +13 more
semanticscholar   +1 more source

Assessing the association between oral hygiene and preterm birth by quantitative light-induced fluorescence [PDF]

, 2014
The aim of this study was to investigate the purported link between oral hygiene and preterm birth by using image analysis tools to quantify dental plaque biofilm.
Adeyemi, Adejumoke A., Burnside, Girvan, Higham, Susan M., Hope, Christopher K., Quenby, Siobhan, Smith, Philip W., Wang, Qian, Whitworth, Melissa   +7 more
core   +4 more sources

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

Genetics of Charcot-Marie-Tooth Disease

Pediatric Neurology Briefs, 1998
The nomenclature, classification, and genetic basis of Charcot-Marie-Tooth (CMT) disease are reviewed from the Department of Molecular and Cell Biology, University of Aberdeen Medical School, Scotland.
J Gordon Millichap
doaj   +1 more source

Periodontitis and the Elderly: An Overview of the Disease and its Impact on an Aging Population [PDF]

, 2019
Periodontitis affects millions of Americans each year, and is especially prevalent among the elderly. Since periodontitis is a chronic, progressive condition, uninterrupted disease progression leads to irreversible oral damage; therefore, periodontitis ...
Weissenfluh, Nicole Grace
core   +1 more source

Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations [PDF]

, 2007
Mfn2, an oligomeric mitochondrial protein important for mitochondrial fusion, is mutated in Charcot-Marie-Tooth disease (CMT) type 2A, a peripheral neuropathy characterized by axonal degeneration.
Chan, David C., Detmer, Scott A.
core   +2 more sources

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Cryogels with controllable physico-chemical properties as advanced delivery systems for biomedical applications

Materials Today Bio
Enhancing the spatiotemporal control of drug delivery holds significant potential for improving drug bioavailability, minimizing adverse reactions and toxicity, and advancing precision medicine. Traditional hydrogels have been widely recognized for their
Mucong Li, Xuyan Wei, Jiaqian You, Jian Feng, Xiuyu Liu, Jing Zhou, Qianju Wu, Yidi Zhang, Yanmin Zhou   +8 more
doaj   +1 more source