Results 31 to 40 of about 129,073 (257)

Generation of functional oligopeptides that promote osteogenesis based on unsupervised deep learning of protein IDRs

Bone Research, 2022
Deep learning (DL) is currently revolutionizing peptide drug development due to both computational advances and the substantial recent expansion of digitized biological data. However, progress in oligopeptide drug development has been limited, likely due
Mingxiang Cai, Baichuan Xiao, Fujun Jin, Xiaopeng Xu, Yuwei Hua, Junhui Li, Pingping Niu, Meijing Liu, Jiaqi Wu, Rui Yue, Yong Zhang, Zuolin Wang, Yongbiao Zhang, Xiaogang Wang, Yao Sun   +14 more
doaj   +1 more source

Establishment of inclusive single-cell transcriptome atlases from mouse and human tooth as powerful resource for dental research

Frontiers in Cell and Developmental Biology, 2022
Single-cell (sc) omics has become a powerful tool to unravel a tissue’s cell landscape across health and disease. In recent years, sc transcriptomic interrogation has been applied to a variety of tooth tissues of both human and mouse, which has ...
Florian Hermans, Florian Hermans, Celine Bueds, Lara Hemeryck, Ivo Lambrichts, Annelies Bronckaers, Hugo Vankelecom   +6 more
doaj   +1 more source

Oxygen and ROS Delivery for Infected Wound Healing and Future Prospects

Advanced Healthcare Materials, EarlyView.
Bacterial infection is a major driver of delayed wound healing and postsurgical readmissions; with rising antibiotic resistance, solid peroxide–releasing biomaterials offer sustained delivery of ROS/O2 for antimicrobial control and microenvironmental modulation.
Ayden Watt, Chably Rachella, Charlotte Jaloux, Joshua Vorstenbosch, Adam Hart, Michael Tanzer, Geraldine Merle, Jake Barralet   +7 more
wiley   +1 more source

Salivary nitrate prevents osteoporosis via regulating bone marrow mesenchymal stem cells proliferation and differentiation

Journal of Orthopaedic Translation
Background: Nitrate, a key component of saliva, has been shown widely physiological functions in the human body. But its function on bone metabolism remains unclear. The aim of this study was to investigate the function and mechanism of saliva nitrate on
Xiaoyu Li, Lei Hu, Xue Wang, Huan Liu, Chunmei Zhang, Jinsong Wang, Xiaogang Wang, Songlin Wang   +7 more
doaj   +1 more source

A novel missense mutation in PLEKHG5 gene causing an intermediate form of autosomal-recessive Charcot–Marie–Tooth disease in an Iraqi family

Egyptian Journal of Medical Human Genetics, 2023
Background Charcot–Marie–Tooth disease comprises a large spectrum of clinically heterogeneous disorders. PLEKHG5 variants have shown an intermediate form of autosomal-recessive Charcot–Marie–Tooth disease C and distal spinal muscular atrophy IV.
Mostafa Neissi, Hadideh Mabudi, Adnan Issa Al-Badran, Javad Mohammadi-Asl, Raed Abdulelah Al-Badran   +4 more
doaj   +1 more source

Crack Repair in Hydroxyapatite Bioceramics Using an Ultraviolet Ultrafast Laser

Advanced Materials Interfaces, EarlyView.
The study proposes an ultrafast ultraviolet laser approach to repair hidden tooth cracks, which has been preliminarily validated on HAP. Moreover, this technique aims to strengthen the native enamel structure rather than introducing a foreign filling material.
Yan Xue, Kai Zheng, Yang Liao, Jing Cao, Xupeng Yuan, Fusong Yuan, Yuxin Leng   +6 more
wiley   +1 more source

Sodium nitrate protects against metabolic syndrome by sialin-mediated macrophage rebalance

Signal Transduction and Targeted Therapy
Metabolic syndrome, characterized by metabolic dysfunction-associated steatotic liver disease (MASLD) and type 2 diabetes mellitus (T2DM), poses a significant threat to patients’ health worldwide; however, efficient treatment is currently unavailable ...
Shaorong Li, Yaning Wang, Zihan Zhang, Haozhe Xu, Songyue Wu, Hua Jin, Xiaotong Han, Ying Liu, Xin Wen, Yi Wu, Zhongtao Zhang, Lei Hu, Liang Hu, Chunmei Zhang, Jinsong Wang, Renhong Yan, Mo Chen, Guozhi Xiao, Guangyong Sun, Dong Zhang, Songlin Wang   +20 more
doaj   +1 more source

Rehabilitation in Charcot-Marie-Tooth disease type 1

Advances in Clinical Neuroscience & Rehabilitation, 2014
Charcot-Marie-Tooth disease is the most common inherited peripheral neuropathy with a prevalence of approximately 1 in 2,500 [1]. The most common subtype is the autosomal dominant type 1A, which is caused by an intrachromosomal duplication on chromosome ...
Manoj Mannil, Chandini Kadian, Elisabeth Futterlieb, Michael W Sereda   +3 more
doaj   +1 more source

Periodontal disease and tooth loss

International Dental Journal, 1998
Numerous epidemiological studies have shown that caries is the main reason for tooth loss. More recent epidemiological data seem to show an increasing trend of tooth loss due to periodontal reasons rather than caries. In considering the issue of periodontal disease and tooth loss the following observations were made.
openaire   +2 more sources

Toward Wireless Implantable Robotic Systems Driven by Magnetic Field for Personalized Therapy

Advanced Robotics Research, EarlyView.
Robotic materials are playing an increasingly vital role in enabling sensing and actuation at small scales. This perspective highlights recent advances in magnetic materials and magnetically actuated devices for wireless sensing, actuation, and energy harvesting toward implantable robotic systems for closed‐loop therapy.
Yusheng Wang, Ruijian Ge, Xiaoguang Dong
wiley   +1 more source