Results 21 to 30 of about 4,945 (221)

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

open access: yesAdvanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes   +14 more
wiley   +1 more source

Tooth Profile Simplified Modeling and Transmission Angle Analysis of Push-rods Oscillatory Transmission with Needle Gears

open access: yes工程科学与技术, 2019
The push-rods oscillatory transmission with needle gears has the advantages of simple structure, convenient manufacturing and high machining precision. For this kind of transmission, the profile equation of movable tooth is the basis for tooth analysis ...
Yu FEI   +4 more
doaj  

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

open access: yesAdvanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu   +6 more
wiley   +1 more source

Design of Face Gear Tooth Surface of Circular Arc Profile

open access: yesJixie chuandong, 2018
In view of the shortcomings of involute gear drive,the advantages of synthetic face gear drive are summarized. The circular arc profile is applied to the face gear,and the gear drive with circular tooth profile is put forward.
Feng Zhanrong, Sheng Wei, Wang Lixia
doaj  

基于MATLAB的双余弦滚动活齿传动的廓线分析

open access: yesJixie chuandong, 2014
A dual-cosine curve of meshing pair which can design a new type of oscillating tooth gear transmission with any tooth-difference is presented and the profile equation of the surge wheel and the internal gear is deduced.By using MATLAB programming for the
聂磊, 杜发荣
doaj  

Immunomagnetic‐MXene Bifunctional Probes for Ultrasensitive and Specific Terahertz Metasensing of Tumor‐Derived Exosomes

open access: yesAdvanced Science, EarlyView.
An immunomagnetic‐MXene bifunctional probe integrated with THz metamaterials enables ultrasensitive and specific detection of pancreatic cancer‐derived exosomes. Dual biomarker recognition ensures high specificity, while MXene signal amplification achieves a detection limit of 647 particles mL−1.
Weidong Jin   +8 more
wiley   +1 more source

Spatiotemporal Regulation of Hierarchical Assembly of Hydroxyapatite for Enamel Remineralization

open access: yesAdvanced Science, EarlyView.
Biomimetic repair exhibits unique advantages for enamel regeneration compared with conventional clinical treatments. An enzymatic mineralization system (EMS) is developed, where the resulting HAP nanorods hierarchically assemble into a highly ordered structure on the enamel surface through the spatiotemporal modulation of interfacial energies of ...
Zhenhang Tang   +15 more
wiley   +1 more source

基于啮合角函数的非圆齿轮齿廓求解及几何特性研究

open access: yesJixie chuandong, 2004
A working pressure angle was defined as a function of an rotation angle of noncircular gears, called the Working-Pressure-Angle (WPA) function. A new method for generating noncircular gear pairs was developed.
林菁
doaj  

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

open access: yesAdvanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin   +6 more
wiley   +1 more source

Study on the Undercut of Circular Arc Tooth Profile Face Gear

open access: yesJixie chuandong, 2018
Aiming at the phenomenon of undercut in the process of circular arc tooth profile face gear,by using the research method combining theoretical analysis,numerical calculation and simulation experiment,the minimum inner radius of the face gear without ...
Sheng Wei, Feng Zhanrong, Wang Lixia
doaj  

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