Results 31 to 40 of about 2,820,928 (238)

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Influence of Walker Curve Tooth Root Modification on Thermoelastic Grease Lubrication Characteristics of Large Internal Gears

Jixie chuandong, 2023
The influence of Walker curve modification method on the tooth surface lubrication state of grease lubricated large internal meshing cylindrical spur gears is studied. According to the meshing law and engineering experience of internal meshing gear pairs,
Wang Zhenbo, Zheng Peng, Zhao Wenhui
doaj  

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

Tooth surface mismatch modification method of cycloidal bevel gear based on conjugate tooth surface modification

Journal of Advanced Mechanical Design, Systems, and Manufacturing, 2020
In order to obtain locally conjugated tooth surface contact, a tooth surface mismatch modification method is proposed based on the fully conjugated characteristics of cycloidal bevel gear.
Jing DENG, Shaowu NIE, Xiaozhong DENG, Chuang JIANG   +3 more
doaj   +1 more source

Customized Itinerant Frequency Combs by Cascaded Nonlinear Effects

Advanced Science, EarlyView.
A cascaded third‐order nonlinear system generates an itinerant frequency comb with the comb center frequency decoupled from the cavity resonance. This enables arbitrary spectral scaling, flexible spacing adjustments, and real‐time central‐frequency engineering, allowing comb splicing and subdivision. The resulting versatility and reconfigurability open
Yi Wang, Yulong Liu, Zeji Li, Wenyan Wang, Sihan Wang, Cheng Wang, Jingwei Zhou, Jie‐Qiao Liao, Tiefu Li   +8 more
wiley   +1 more source

Immunomagnetic‐MXene Bifunctional Probes for Ultrasensitive and Specific Terahertz Metasensing of Tumor‐Derived Exosomes

Advanced Science, EarlyView.
An immunomagnetic‐MXene bifunctional probe integrated with THz metamaterials enables ultrasensitive and specific detection of pancreatic cancer‐derived exosomes. Dual biomarker recognition ensures high specificity, while MXene signal amplification achieves a detection limit of 647 particles mL−1.
Weidong Jin, Jiyue Chen, Fengxin Xie, Huiyan Tian, Xuechen Dou, Yanqi Han, Lu Zhang, Jining Li, Xiang Yang   +8 more
wiley   +1 more source

Multi-objective Orthogonal Test Simulation and Modification Parameter Design based on Ease-off Topology

Jixie chuandong, 2022
To improve the comprehensive dynamic meshing performance of a certain gear product， a design method for controlling the polynomial coefficients of the topological modification of the tooth surface is proposed.
Jiaqi Li, Congcong Song, Bingyang Wei
doaj  

Spatiotemporal Regulation of Hierarchical Assembly of Hydroxyapatite for Enamel Remineralization

Advanced Science, EarlyView.
Biomimetic repair exhibits unique advantages for enamel regeneration compared with conventional clinical treatments. An enzymatic mineralization system (EMS) is developed, where the resulting HAP nanorods hierarchically assemble into a highly ordered structure on the enamel surface through the spatiotemporal modulation of interfacial energies of ...
Zhenhang Tang, Zhisen Zhang, Yuanyu Zhou, Wenzhi Wu, Congrui Zhao, Chang Liu, Tong Shi, Wenjing Jin, Zhaoming Liu, Weifeng Fang, Qingyun Lin, Yi He, Zhijian Xie, Ruikang Tang, Changyu Shao, Zhuo Chen   +15 more
wiley   +1 more source

Theoretical Research of the Modification of Cycloidal Gear used in RV Reducer of Robot

Jixie chuandong, 2015
Aiming at the cycloidal gear used in RV reducer of robots,based on the concept of the single tooth without side clearance,the tooth surface equation of the cycloidal gear after modification is deduced by directly adding the second- order parabolic ...
Zhao Bo, Deng Xiaozhong, Li Tianxing, Su Jianxin   +3 more
doaj