Results 41 to 50 of about 2,693,515 (272)

A New Modification Method with Double Spline Curve for the Tooth Surface Design of Spur Gear

Jixie chuandong, 2021
A new tooth surface design is proposed to spur gears with a tooth surface modification defined by double spline curves， which are used to represent the tooth profile and longitudinal profile， respectively.
Wenjun Fan, Yuansheng Zhou, Xueqing Wang, Jinyuan Tang   +3 more
doaj  

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Large‐Area Flat Optics Color Routing in Tilted Arrays of 2D Semiconductor Nanostripes

Advanced Optical Materials, EarlyView.
We develop a scalable flat optics platform exploiting self‐organised ion‐beam sputtering and maskless glancing‐angle deposition to fabricate centimetre‐scale arrays of tilted MoS2 nanostripes. The engineered geometry activates Rayleigh anomalies, guided modes, and Mie resonances, enabling highly directional color routing and enhanced light harvesting ...
Simone Di Marco, Daniele Ceneda, Matteo Barelli, Matteo Gardella, Rajesh Chennuboina, Maria C. Giordano, Marco Centini, Francesco Buatier de Mongeot   +7 more
wiley   +1 more source

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Theoretical Research of the Modification of Cycloidal Gear Used in High Precision RV Reducer

Jixie chuandong, 2018
The second-order logarithmic superposition of modification quantity along the normal direction to the theory of conjugate tooth profile of cycloid gear of RV reducer is carried out,the cycloid tooth profile equation after the modification is deduced.
Ke Qingxun, Deng Xiaozhong, Su Jianxin, Nie Shaowu, Geng Longlong, Liang Shuaifeng   +5 more
doaj  

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

A New Design of the Tooth Profile for Single Screw Compressors [PDF]

, 2012
The wear of star wheel teeth is an importance issue in the single screw compressor. In order to enhance the wearresistance of star wheel teeth, some new profiles of the meshing pair were proposed to replace the currently used straight line envelope ...
Feng, Quanke, Wu, Weifeng, Liu, Feilong, Li, Jian   +3 more
core   +1 more source

TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis

Advanced Science, EarlyView.
A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu, Tiancheng Li, Yu Jin, Yixin Li, Qicheng Liu, Runzhe Fang, Luyao Qu, Xinyue Tang, Ruomei Li, Xiaoyue Zhao, Jin Hao, Bing Fang, Lunguo Xia   +12 more
wiley   +1 more source

Pitting damage levels estimation for planetary gear sets based on model simulation and grey relational analysis [PDF]

, 2011
The planetary gearbox is a critical mechanism in helicopter transmission systems. Tooth failures in planetary gear sets will cause great risk to helicopter operations.
Gu, Fengshou, Hu, Niaoqing, Cheng, Zhe, Qin, Guojun   +3 more
core   +3 more sources