Results 61 to 70 of about 3,217,305 (276)

PIAS3 CircRNA‐Loaded Lipid Nanoparticles Restore ALOX15 SUMOylation to Suppress Cementoblast Ferroptosis and Attenuate Orthodontically Induced Root Resorption

Advanced Science, EarlyView.
Orthodontic compression suppresses PIAS3 expression in cementoblasts, impairing ALOX15 SUMOylation and ubiquitin‐mediated degradation, which leads to ALOX15 accumulation, lipid peroxidation, ferroptosis, and osteoclastogenesis. Local delivery of PIAS3 circRNA‐loaded lipid nanoparticles restores the PIAS3–ALOX15 regulatory pathway, alleviates ...
Yifei Hou, Chongzheng Yan, Xinrui Xu, Zihan Yang, Xinhui Wu, Hongxu Zhao, Xuan Song, Jianing Zhang, Yijing Li, Aohua Yang, Xiamei Lu, Yi Liu   +11 more
wiley   +1 more source

Theoretical Research of the Modification of Cycloidal Gear used in RV Reducer of Robot

Jixie chuandong, 2015
Aiming at the cycloidal gear used in RV reducer of robots,based on the concept of the single tooth without side clearance,the tooth surface equation of the cycloidal gear after modification is deduced by directly adding the second- order parabolic ...
Zhao Bo, Deng Xiaozhong, Li Tianxing, Su Jianxin   +3 more
doaj  

A Rare Form of Microcephalic Primordial Dwarfism due to NSMCE2 Deficiency (Seckel Syndrome Type 10): A Report of Macular Involvement

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Biallelic variants in NSMCE2 (MMS21), which encodes the SUMO E3 ligase subunit of the SMC5/6 chromatin‐maintenance complex, have recently been implicated in microcephalic primordial dwarfism (MPD), corresponding to Seckel syndrome type 10 (OMIM #617246).
Cristina Peduto, Céline Huber, Clément Paya, Isabelle Audo, Nathalie Boddaert, Valérie Cormier‐Daire   +5 more
wiley   +1 more source

Research on thermal characteristics of gear based on parametric tooth profile modification

Advances in Mechanical Engineering
This paper establishes a thermal analysis model for parametric profile modification gears based on the heat transfer mechanisms of gear transmission. The main research parameters are the addendum coefficient and the modification coefficient, focusing on ...
Hengzhe Shi, Wei Li, Wanlin Zhou
doaj   +1 more source

Influence of Tip Relief Profile Modification on Involute Spur Gear Stress [PDF]

, 2016
This paper deals with the effects of linear tip profile modification on the stress of tooth root and tooth flank of involute spur gears. An increase in the tooth flank stress due to the tip profile modification is potentially hazardous because there is ...
Marković, Kristina, Vrcan, Željko
core   +1 more source

Biallelic PIGB Variants Cause Motor Neuropathy with Conduction Blocks and Peripheral Nerve Hyperexcitability

Annals of Neurology, EarlyView.
Objective Glycosylphosphatidylinositol (GPI)‐anchored proteins play critical roles in nervous system function. Pathogenic variants in genes involved in GPI‐anchor biosynthesis cause early‐onset multisystem disorders known as inherited GPI deficiencies. We describe a novel neuromuscular phenotype associated with PIGB deficiency.
Gorka Fernández‐Eulate, Romain Duval, Marina Konyukh, Alessandro Bertini, Ayse Candayan, Albena Jordanova, Theresa Brunet, Wolfgang Müller‐Felber, Helena F. Pernice, Katrin Hahn, Nadja Ehmke, Juliane Beuschlein, Bertrand Isidor, Benjamin Cogné, Yann Péréon, Annabelle Chaussenot, John Rendu, Aysylu Murtazina, Dmitrii Subbotin, Artem Borovikov, Andrey Marakhonov, Chiara Pisciotta, Paola Saveri, Daniele Cazzato, Lucie Lemeray, Bérengère Koehl, Jean‐Madeleine de Sainte‐Agathe, Stefano Facchini, Ilaria Quartesan, Andrea Cortese, Yesim Parman, Arman Cakar, Davide Pareyson, Slim Azouzi, Tanya Stojkovic   +34 more
wiley   +1 more source

Study on the Precise Modeling Method of Helical Gear with Deviation and Modification

Jixie chuandong, 2018
According to the forming process principle,the influence of the tooth profile modification,helix modification and tooth profile deviation,helix deviation and eccentricity tolerance of radial run-out of the involute helical gear on tooth profile shape is ...
Yuan Yongchao, Liu Zhongming, Mao Jizhe, Cao Yanjun, Zhang Kun   +4 more
doaj  

METHOD FOR MODIFYING PROFILE OF CYCLOIDAL WHEEL CONSIDERING COMPENSATION FOR ELASTIC DEFORMATION

Jixie qiangdu, 2020
Considering the influence of elastic deformation on the profile of the cycloid,a cycloid profile modification method for compensating elastic deformation is proposed.Based on the theory of cycloid profile modification,the coordinates of the meshing point
QIN ZhengZheng, WANG Quan, ZHAO DaXing, WANG Jun, ZENG LiLei   +4 more
doaj  

Rethinking brachycephaly: Anatomical implications and health considerations in lagomorphs

The Anatomical Record, EarlyView.
Abstract Brachycephaly in domestic rabbits is increasingly perceived by welfare organizations as associated with significant health complications, particularly oral pathologies. Despite this perception, comparative anatomical research into rabbit brachycephaly is limited compared to that of dogs and cats, compelling an in‐depth examination of its ...
Helaina Cressy, Alice Nishigaki, Matthew C. Gage, Renato L. Previdelli   +3 more
wiley   +1 more source

Cortical bone distribution in the human mandibular symphysis: Ontogenic and morphometric approaches in archeological context

The Anatomical Record, EarlyView.
Abstract The human mandibular symphysis concentrates multiaxial loads during function and remodels throughout growth, but the precise mechanisms underlying cortical bone shape during growth remain relatively unexplored. Approaches based solely on thickness or external cortical contours provide only partial insights and do not capture the functional ...
Ana Ribeiro, Elsa Garot, Christine Couture, Pierre‐Hadrien Decaup   +3 more
wiley   +1 more source