Results 221 to 230 of about 2,693,515 (272)

Identification of Copy Number Variants as a Suspected Cause of Cerebral Small Vessel Disease

open access: yesClinical Genetics, EarlyView.
Whole‐exome sequencing of 111 patients with suspected familial cerebral small vessel disease (CSVD) identified novel copy number variants in four patients across NOTCH3, LMNB1, and COL4A2, using bioinformatic and molecular techniques. These validated CNVs suggest structural variation is an underrecognized potential causal contributor to monogenic CSVD ...
Solomon K. Guyler   +5 more
wiley   +1 more source

A revised classification system of the marronoid clade of spiders (Araneae), based on dense sampling phylogenomics and comparative morphology

open access: yesCladistics, EarlyView.
Abstract The marronoid clade is a globally distributed, ecologically diverse group of spiders. It is an important faunal component in both natural and synanthropic environments, and even found in aquatic and extreme habitats such as desert salt flats. The systematics of the marronoid clade has been notoriously unstable due to the widespread character ...
Jonas O. Wolff   +10 more
wiley   +1 more source

Clinical Outcomes of Fixed Dental Prostheses Supported by Teeth or Implants in the Posterior Region—A Long‐Term Retrospective Multicenter Study

open access: yesClinical Oral Implants Research, EarlyView.
ABSTRACT Background Few long‐term studies compare tooth‐ and implant‐supported fixed dental prostheses (FDPs) in the posterior region. Objectives To compare the 5‐ and 10‐year survival and complication outcomes of tooth‐ and implant‐supported FDPs and to assess patient‐reported effects. Material and Methods This retrospective multicenter clinical study
Zahra Athab Abduljabbar   +5 more
wiley   +1 more source

Risk Factors for Implant Failure and Peri‐Implantitis: A Retrospective Cohort Study

open access: yesClinical Oral Implants Research, EarlyView.
ABSTRACT Objectives This retrospective cohort study evaluated patient‐, implant‐, site‐, procedural‐, biological‐, and prosthesis/mechanics‐related factors associated with early and late implant failure and peri‐implantitis. Material and Methods Electronic health record data from a university center were analyzed.
Nathalia Vilela   +4 more
wiley   +1 more source

Dental Pulp Stem Cell‐Derived Intracellular Vesicles Inhibit OSCC by Delivering PTEN to Suppress PI3K/AKT/mTOR Signalling Pathway

open access: yesCell Proliferation, EarlyView.
DPSC‐IVs suppressed PI3K/AKT/mTOR signalling pathway by delivering PTEN to tumour cells, which reduced the expression of Bcl‐2 and elevated that of Bax. Meanwhile, DPSC‐IVs activated PINK1/Parkin mediated mitophagy, which further raised ROS levels.
Yu Luo   +10 more
wiley   +1 more source

Periodontitis‐Associated Circulating EVs Promote Colorectal Cancer Progression via Carnosine‐Mediated Acidosis Adaptation

open access: yesCell Proliferation, EarlyView.
This study identifies a link between periodontitis and CRC progression mediated by carnosine‐enriched circulating EVs. These EVs target the intestine and elevate tumour cell intracellular pH (pHi), which rescues lysosomal function. This process drives a transition from dysfunctional lysosomes to functional ones, promoting a high malignancy phenotype in
Ruoyi Wu   +15 more
wiley   +1 more source

On the stability analysis of gear pairs with tooth profile modification

open access: yesMechanism and Machine Theory, 2022
Stephanos Theodossiades
exaly   +2 more sources

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