Results 81 to 90 of about 215,489 (356)

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source

Downregulation of FGF Signaling by Spry4 Overexpression Leads to Shape Impairment, Enamel Irregularities, and Delayed Signaling Center Formation in the Mouse Molar. [PDF]

, 2019
FGF signaling plays a critical role in tooth development, and mutations in modulators of this pathway produce a number of striking phenotypes. However, many aspects of the role of the FGF pathway in regulating the morphological features and the mineral ...
Ahn, Youngwook, Charles, Cyril, Ganss, Bernhard, Jheon, Andrew, Klein, Ophir D, Krumlauf, Robb, Marangoni, Pauline, Seidel, Kerstin, Viriot, Laurent   +8 more
core   +1 more source

Arginine Methylation Antagonizes TEAD3‐Mediated Repression to Promote Osteogenic Differentiation by Disrupting RUNX2‐Sequestrating Condensates

Advanced Science, EarlyView.
In the unmethylated state, TEAD forms stable, repressive condensates that sequester the osteogenic master regulator RUNX2. Arginine methylation of TEAD at R55 acts as a molecular brake, dissolving these condensates to release RUNX2 and activate the osteogenic program.
Lei Cao, Ruohui Han, Hui Xiong, Qian Li, Shaofei Tao, Xudong Wu, Dayong Liu   +6 more
wiley   +1 more source

Multidisciplinary Treatment Of Fracture And Luxation Of Immature Permanent Teeth

International Dental Journal
Introduction: The management of anterior tooth luxation with concomitant subgingival root fracture necessitates a multidisciplinary approach that considers biological, functional, and aesthetic factors.
Haojie Yu, Zhu Haihua, Zhu Fudong
doaj   +1 more source

Antagonistic interaction between Ezh2 and Arid1a coordinates root patterning and development via Cdkn2a in mouse molars

eLife, 2019
Patterning is a critical step during organogenesis and is closely associated with the physiological function of organs. Tooth root shapes are finely tuned to provide precise occlusal support to facilitate the function of each tooth type.
Junjun Jing, Jifan Feng, Jingyuan Li, Xia Han, Jinzhi He, Thach-Vu Ho, Jiahui Du, Xuedong Zhou, Mark Urata, Yang Chai   +9 more
doaj   +1 more source

Induced Ankylosis of a Primary Molar for Skeletal Anchorage in the Mandible as Alternative to Mini-Implants [PDF]

, 2015
Background Mesial protraction of mandibular posterior teeth requires increased anchorage to avoid undesired tooth movements. Orthodontic mini-implants have become a popular and successful way to increase skeletal anchorage in such cases.
Angelopoulou, Matina V., Halazonetis, Demetrios J., Koletsi, Despina, Vadiakas, George   +3 more
core   +2 more sources

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Accurate Finite Element Modeling Method of Herringbone Gear based on Multipoint Constraint Method

Jixie chuandong, 2022
A sufficiently refined mesh at the stress position is the basis for finite element analysis of gears to obtain accurate tooth surface contact stress and tooth root bending stress.
Guanwang Geng, Wei Liu, Qingsong Zhang
doaj  

Possibilities of cone-beam computed tomography in the diagnosis of longitudinal fractures of the roots of teeth

Эндодонтия Today, 2020
A vertical fracture of the tooth root, which is not diagnosed in time, may lead to periodontitis. On the other hand, if the root fracture is diagnosed, whereas in fact it is not, then the patient will remove the tooth on the basis of an error in the ...

doaj   +1 more source

Influence of linear profile modification and loading conditions on the dynamic tooth load and stress of high contact ratio gears [PDF]

A computer simulation for the dynamic response of high-contact-ratio spur gear transmissions is presented. High contact ratio gears have the potential to produce lower dynamic tooth loads and minimum root stress but they can be sensitive to tooth profile
Lee, Chinwai, Lin, Hsiang Hsi, Oswald, Fred B., Townsend, Dennis P.   +3 more
core   +1 more source