Results 51 to 60 of about 2,282 (237)

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

Overwintering of Eight Toothed Spruce Bark Beetle (Ips typographus) in Spruce Forests of North Velebit

Croatian Journal of Forest Engineering, 2011
The eight toothed spruce bark beetle (Ips typographus) plays an important role in spruce forests of Croatia, in the same way as it does in the rest of Europe wherever spruce grows. The size and intensity of its outbreaks is considerably lower though, and
Boris Hrašovec, Luka Kasumović, Milivoj Franjević   +2 more
doaj  

Localizations of Laminin Chains Suggest Their Multifaceted Functions in Mouse Tooth Development

International Journal of Molecular Sciences
The human laminin family is composed of five α, four β, and three γ chains. Laminins are heterotrimers of α, β, and γ chains. Laminins play critical roles during organogenesis, mostly as basement membrane components. The expression of all and the localization of most laminin chains were characterized in mouse developing teeth.
Tian Liang, Hong Zhang, Yuanyuan Hu, Mansi Solanki, Chuhua Zhang, Takako Sasaki, Charles E. Smith, Jan C.-C. Hu, James P. Simmer   +8 more
openaire   +2 more sources

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Overwintering of Eight Toothed Spruce Bark Beetle (Ips typographus) in Spruce Forests of North Velebit

Croatian Journal of Forest Engineering, 2011
The eight toothed spruce bark beetle (Ips typographus) plays an important role in spruce forests of Croatia, in the same way as it does in the rest of Europe wherever spruce grows. The size and intensity of its outbreaks is considerably lower though, and
Milivoj Franjević, Luka Kasumović, Boris Hrašovec   +2 more
doaj  

Localization of type IV collagen alpha chains in tooth germ development

Journal of Hard Tissue Biology, 2005
The morphogenesis and morphological development of molar are regulated by the interaction between odontogenic epithelium and mesenchymal tissues. And Type IV collagen molecules, the major component of the dental basement membrane, are composed of three alpha chains.
Katase, Naoki, Nagatsuka, Hitoshi, Nakano, Keisuke, Tamamura, Ryo, Xie, Wel-li, Matsuoka, Yukiteru, Nagai, Noriyuki   +6 more
openaire   +2 more sources

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Identification of an Osteochondral Erosion Process in Gout Driven by Fibrinogen‐Integrin Activation and Local MSU Crystallization

Advanced Science, EarlyView.
Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu, Simin Bi, Zhechen Liu, Xiaofeng Zhou, Hengwei Qin, Nicola Dalbeth, Minbiao Ji, Yinghui Hua   +7 more
wiley   +1 more source

STUDY OF THE PERFORMANCE OF PLANETARY REDUCTIONS WITH FINEMODULAR TOOTH CHAINS

ETM - Equipment, Technologies, Materials
Currently, top drive systems (TDS) consisting of a motor and a swivel-reducer that rotate the drill string are used to solve technological problems of drilling directional and horizontal wells. The main problems of ensuring strength when creating machines include: the occurrence of sudden failures of machine parts; ensuring a certain safety margin ...
openaire   +1 more source