Results 91 to 100 of about 1,538,506 (330)

The Facets of Place [PDF]

open access: yes, 1996
This chapter will outline one theory aimed at integrating aspects of environmental psychology with issues in architectural design. The theory to be reviewed is broad in those characteristics of theory that Moore (1987) called their 'form and scope ...
Canter, David V.
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Computer-aided design of nano-filter construction using DNA self-assembly

open access: yesNanoscale Research Letters, 2006
Computer-aided design plays a fundamental role in both top-down and bottom-up nano-system fabrication. This paper presents a bottom-up nano-filter patterning process based on DNA self-assembly.
Mohammadzadegan Reza, Mohabatkar Hassan
doaj   +1 more source

STUDENTS’ READING STRATEGIES AT ENGLISH EDUCATIONAL DEPARTMENT

open access: yesAl-Ishlah: Jurnal Pendidikan, 2019
Reading comprehension is one of the skills that students must have to enrich their knowledge, especially university students. There are two kinds of reading strategies: Top – Down strategy and Bottom – Up Strategy.
Utami Dewi, Maryati Salmiah
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Small amphipathic peptides are responsible for the assembly of cruciferin nanoparticles

open access: yesScientific Reports, 2017
Amphipathic peptides are versatile building blocks for fabricating well-ordered nanostructures, which have gained much attention owing to their enormous design possibilities and bio-functionalities.
Hui Hong, Ali Akbari, Jianping Wu
doaj   +1 more source

Citizen centered design

open access: yesIn_Bo, 2015
Today architecture has to design for rapidly changing futures, in a citizen-centered way. That is, architecture needs to embrace meaningful design. Societal challenges ask for a new paradigm in city-making, which combines top-down public management with ...
Ingrid Mulder
doaj   +1 more source

The benefits of bottom-up design [PDF]

open access: yes
An inconsistency is examined in generic top-down design methods and standards employed in the implementation of reliable software. Many design approaches adopt top-down ordering when defining the structure, interfaces, and processing of a system. However,
Mcfarland, Gregory
core   +1 more source

Staff development at RMIT: Bottom‐up work serviced by top‐down investment and policy [PDF]

open access: yes, 2000
Effective staff development is the weaving together of many strands. We need to support staff in their current work, while providing them with ideas, incentives and resources to look for new ways to design learning environments which will enhance student
Kennedy, Paul, McNaught, Carmel
core   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

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