Results 91 to 100 of about 1,624,943 (326)
Small amphipathic peptides are responsible for the assembly of cruciferin nanoparticles
Scientific Reports, 2017 Amphipathic peptides are versatile building blocks for fabricating well-ordered nanostructures, which have gained much attention owing to their enormous design possibilities and bio-functionalities.
Hui Hong, Ali Akbari, Jianping Wu
doaj +1 more source
In_Bo, 2015 Today architecture has to design for rapidly changing futures, in a citizen-centered way. That is, architecture needs to embrace meaningful design. Societal challenges ask for a new paradigm in city-making, which combines top-down public management with ...
Ingrid Mulder
doaj +1 more source
, 1996 This chapter will outline one theory aimed at integrating aspects of environmental psychology with issues in architectural design. The theory to be reviewed is broad in those characteristics of theory that Moore (1987) called their 'form and scope ...
Canter, David V.
core
Modular architecture of the microfactories for automatic micro-assembly. [PDF]
, 2010 International audienceThe construction of a new generation of MEMS which includes micro-assembly steps in the current microfabrication process is a big challenge.
Gauthier, Michaël +3 more
core +3 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Heliyon, 2020 Nanotechnology has been widely developed to improve the solubility of active pharmaceutical ingredients. Co-crystal discovery has also taken much attention in drug design and development.
Ilma Nugrahani, Winni Nur Auli
doaj +1 more source
The benefits of bottom-up design [PDF]
An inconsistency is examined in generic top-down design methods and standards employed in the implementation of reliable software. Many design approaches adopt top-down ordering when defining the structure, interfaces, and processing of a system. However,
Mcfarland, Gregory
core +1 more source
Staff development at RMIT: Bottom‐up work serviced by top‐down investment and policy [PDF]
, 2000 Effective staff development is the weaving together of many strands. We need to support staff in their current work, while providing them with ideas, incentives and resources to look for new ways to design learning environments which will enhance student
Kennedy, Paul, McNaught, Carmel
core +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Evolving Symbolic Controllers [PDF]
, 2003 International audienceThe idea of symbolic controllers tries to bridge the gap between the top-down manual design of the controller architecture, as advocated in Brooks' subsumption architecture, and the bottom-up designer-free approach that is now ...
D. Floreano +5 more
core +3 more sources