Results 91 to 100 of about 1,475,669 (329)
Changing work engagement: The longitudinal effect of a job redesign intervention among public sector employees [PDF]
Strategic Management, 2017 Work or employee engagement might be increased through job re-design interventions such as top-down managerial interventions, bottom-up job crafting or bipolar ideals.
Hernaus Tomislav +2 more
doaj
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
The benefits of bottom-up design [PDF]
An inconsistency is examined in generic top-down design methods and standards employed in the implementation of reliable software. Many design approaches adopt top-down ordering when defining the structure, interfaces, and processing of a system. However,
Mcfarland, Gregory
core +1 more source
TOP-DOWN AND BOTTOM-UP PROCESSING IN LISTENING. WHICH ONE IS PROBLEMATIC?: A CASE OF UNIVERSITAS PGRI SEMARANG [PDF]
, 2015 To enhance students’ ability in listening skill, the lecturer needs to understand what problems faced by their students. Since listening is still a big issue for English learners in Indonesia, so the processing of Top Down and Bottom Up need to be ...
Ardini, Sukma Nur
core +3 more sources
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
A "Social Bitcoin" could sustain a democratic digital world [PDF]
, 2016 A multidimensional financial system could provide benefits for individuals, companies, and states. Instead of top-down control, which is destined to eventually fail in a hyperconnected world, a bottom-up creation of value can unleash creative potential ...
Helbing, Dirk, Kleineberg, Kaj-Kolja
core +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Renewal of Buenos Aires city waterfront [PDF]
, 2010 This paper reports an analysis of the main phases and factors relevant to the renovation of the coastal area of the city of Buenos Aires. Since the early 1980s, and especially with the country's comeback of democratic life, that area developed along two ...
Faggi, Ana Maria
core +1 more source
Assessing the design of integrated methane sensing networks
Environmental Research LettersWhile methane is the second largest contributor to global warming after carbon dioxide, it has a larger warming effect over a much shorter lifetime. Despite accelerated technological efforts to radically reduce global carbon dioxide emissions, rapid ...
Lekha Patel, Jake P Zenker
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source