Results 101 to 110 of about 1,548,118 (340)
Heliyon, 2020 Nanotechnology has been widely developed to improve the solubility of active pharmaceutical ingredients. Co-crystal discovery has also taken much attention in drug design and development.
Ilma Nugrahani, Winni Nur Auli
doaj +1 more source
Hypnotic suggestion versus sensory modulation of bodily awareness.
PLoS ONE, 2023 Bodily awareness arises from somatosensory, vestibular, and visual inputs but cannot be reduced to these incoming sensory signals. Cognitive factors are known to also impact bodily awareness, though their specific influence is poorly understood.
C Apelian, D B Terhune, F De Vignemont
doaj +1 more source
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
The benefits of bottom-up design [PDF]
An inconsistency is examined in generic top-down design methods and standards employed in the implementation of reliable software. Many design approaches adopt top-down ordering when defining the structure, interfaces, and processing of a system. However,
Mcfarland, Gregory
core +1 more source
, 1996 This chapter will outline one theory aimed at integrating aspects of environmental psychology with issues in architectural design. The theory to be reviewed is broad in those characteristics of theory that Moore (1987) called their 'form and scope ...
Canter, David V.
core
Evaluating practitioner cyber-security attack graph configuration preferences [PDF]
, 2018 Attack graphs and attack trees are a popular method of mathematically and visually rep- resenting the sequence of events that lead to a successful cyber-attack.
Bal, Jay +2 more
core +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Ab initio Computational Study of Quantum Plasmons in Graphene Nanoflakes [PDF]
, 2017 We investigate the potential merit in using nanometer-sized graphene flakes as building blocks of twodimensional (2D) quantum metamaterials. The choice of the building blocks is crucial to the design of quantum metamaterials with desired properties ...
Manrique, DZ, Panoiu, NC
core
Evolving Symbolic Controllers [PDF]
, 2003 International audienceThe idea of symbolic controllers tries to bridge the gap between the top-down manual design of the controller architecture, as advocated in Brooks' subsumption architecture, and the bottom-up designer-free approach that is now ...
D. Floreano +5 more
core +3 more sources