Results 101 to 110 of about 1,538,506 (330)
Heliyon, 2020 Nanotechnology has been widely developed to improve the solubility of active pharmaceutical ingredients. Co-crystal discovery has also taken much attention in drug design and development.
Ilma Nugrahani, Winni Nur Auli
doaj +1 more source
Evolving Symbolic Controllers [PDF]
, 2003 International audienceThe idea of symbolic controllers tries to bridge the gap between the top-down manual design of the controller architecture, as advocated in Brooks' subsumption architecture, and the bottom-up designer-free approach that is now ...
D. Floreano +5 more
core +3 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Policy effectiveness and “misalignment” with firms’ strategies: A study of pro-internationalization incentives [PDF]
, 2014 Purpose: This paper aims to seek to demonstrate that a non-scientific approach to policy design causes policymakers to persist in the development and use of conventional and inefficient top-down policies.
Clegg, LJ, Torres, MM
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Changing work engagement: The longitudinal effect of a job redesign intervention among public sector employees [PDF]
Strategic Management, 2017 Work or employee engagement might be increased through job re-design interventions such as top-down managerial interventions, bottom-up job crafting or bipolar ideals.
Hernaus Tomislav +2 more
doaj
Critical success factors of a bottom up urban design process to deliver sustainable urban designs [PDF]
A sustainable urban environment caters for peoples’ need. When the needs of the people are addressed, it increases the property values and attracts investors.
Amaratunga, Dilanthi +3 more
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Assessing the design of integrated methane sensing networks
Environmental Research LettersWhile methane is the second largest contributor to global warming after carbon dioxide, it has a larger warming effect over a much shorter lifetime. Despite accelerated technological efforts to radically reduce global carbon dioxide emissions, rapid ...
Lekha Patel, Jake P Zenker
doaj +1 more source