Results 101 to 110 of about 1,624,943 (326)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Changing work engagement: The longitudinal effect of a job redesign intervention among public sector employees [PDF]

Strategic Management, 2017
Work or employee engagement might be increased through job re-design interventions such as top-down managerial interventions, bottom-up job crafting or bipolar ideals.
Hernaus Tomislav, Tadić-Vujčić Maja, Aleksić Ana   +2 more
doaj  

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Changes in electrophysiological markers of cognitive control after administration of galantamine

NeuroImage: Clinical, 2018
The healthy brain is able to maintain a stable balance between bottom-up sensory processing and top-down cognitive control. The neurotransmitter acetylcholine plays a substantial role in this.
Lauren E. Gascoyne, Karen J. Mullinger, Siân E. Robson, Jyothika Kumar, George C. O'Neill, Lena Palaniyappan, Peter G. Morris, Elizabeth B. Liddle, Matthew J. Brookes, Peter F. Liddle   +9 more
doaj   +1 more source

Critical success factors of a bottom up urban design process to deliver sustainable urban designs [PDF]

A sustainable urban environment caters for peoples’ need. When the needs of the people are addressed, it increases the property values and attracts investors.
Amaratunga, Dilanthi, Curwell, S., Dias, N., Keraminiyage, Kaushal   +3 more
core  

Ab initio Computational Study of Quantum Plasmons in Graphene Nanoflakes [PDF]

, 2017
We investigate the potential merit in using nanometer-sized graphene flakes as building blocks of twodimensional (2D) quantum metamaterials. The choice of the building blocks is crucial to the design of quantum metamaterials with desired properties ...
Manrique, DZ, Panoiu, NC
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Assessing the design of integrated methane sensing networks

Environmental Research Letters
While methane is the second largest contributor to global warming after carbon dioxide, it has a larger warming effect over a much shorter lifetime. Despite accelerated technological efforts to radically reduce global carbon dioxide emissions, rapid ...
Lekha Patel, Jake P Zenker
doaj   +1 more source

New bottom-up algorithm for assembly plan generation : opportunities for micro-factory design. [PDF]

, 2007
International audienceThis paper discusses a new approach dedicated to assembly plan generation, called "bottom-up algorithm". It is compared to the traditional "top-down approach", usually used to perform this stage of the design process of the assembly
Lutz, Philippe, Perrard, Christophe, Salgueiro, Paulo   +2 more
core   +2 more sources