Results 111 to 120 of about 4,098,484 (351)
The benefits of bottom-up design [PDF]
An inconsistency is examined in generic top-down design methods and standards employed in the implementation of reliable software. Many design approaches adopt top-down ordering when defining the structure, interfaces, and processing of a system. However,
Mcfarland, Gregory
core +1 more source
, 1996 This chapter will outline one theory aimed at integrating aspects of environmental psychology with issues in architectural design. The theory to be reviewed is broad in those characteristics of theory that Moore (1987) called their 'form and scope ...
Canter, David V.
core
Molecular Oncology, Volume 19, Issue 4, Page 1117-1131, April 2025.This study shows that patients with gastrointestinal adenocarcinomas can be stratified into six distinct subtypes based on genome‐scale DNA methylation profiling. This stratification, achieved using a robust analytical framework, aligns with established tumor characteristics and holds potential to support prognostication.
Rita Pinto +3 more
wiley +1 more source
Design Spaces and How Software Designers Use Them: a sampler [PDF]
In Proceedings of the 1st International Workshop on Designing
Software (Designing '24), 2024. Association for Computing Machinery, New
York, NY, USA, pp. 1-8Discussions of software design often refer to using "design spaces" to describe the spectrum of available design alternatives. This supports design thinking in many ways: to capture domain knowledge, to support a wide variety of design activity, to analyze or predict properties of alternatives, to understand interactions and dependencies among design ...
arxiv +1 more source
Molecular Oncology, EarlyView.Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran +16 more
wiley +1 more source
Multi‐omics profiling reveals key factors involved in Ewing sarcoma metastasis
Molecular Oncology, Volume 19, Issue 4, Page 1002-1028, April 2025.Using a mouse model that recapitulates the spread of tumor cells within the body, we have profiled paired tumors and metastasis samples using a multiomics approach combining different layers of biological information. We identified key genes that drive metastasis in Ewing sarcoma.
Mariona Chicón‐Bosch +11 more
wiley +1 more source
Assessing the design of integrated methane sensing networks
Environmental Research LettersWhile methane is the second largest contributor to global warming after carbon dioxide, it has a larger warming effect over a much shorter lifetime. Despite accelerated technological efforts to radically reduce global carbon dioxide emissions, rapid ...
Lekha Patel, Jake P Zenker
doaj +1 more source
Trophic control of saltmarsh invertebrates [PDF]
, 2008 Top-down (consumer) versus bottom-up (resource) control of food webs has long interested ecologists. Here, I take advantage of a full-factorial design of ecosystem-wide manipulations of nutrient additions (loading rates 10x above background) and the ...
Johnson, David Samuel
core +2 more sources
KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells
Molecular Oncology, Volume 19, Issue 5, Page 1404-1421, May 2025.We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock +10 more
wiley +1 more source
Curriculum Designs: Top-down or Bottom-up? —A Case Study in a Technological School of China
Theory and Practice in Language Studies, 2019 Competitive education around the world brings up many issues about curriculum design. In order to cultivate the ideal talents with abundant knowledge of language and specialties, it is necessary to design appropriate curricula. This comparative study has been carried out to discuss the appropriateness of curriculum designed for two parallel groups of ...
openaire +2 more sources