Results 121 to 130 of about 1,624,943 (326)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Science and Technology of Nuclear Installations, 2012 A general evaluation methodology development and application process (EMDAP) paradigm is described for the resolution of severe accident safety issues.
Robert P. Martin
doaj +1 more source
The FEM-2 parallel computer is designed using methods differing from those ordinarily employed in parallel computer design. The major distinguishing aspects are: (1) a top-down rather than bottom-up design process; (2) the design considers the entire ...
Adams, L. M. +5 more
core +1 more source
Designing Instructional Materials for Teaching Listening Comprehension [PDF]
, 1988 An approach to the design of listening comprehension materials and classroom activities reflects a view of the nature of listening and the processes it involves.
Richards, Jack
core
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
20% by 2020? Economy-wide impacts of energy efficiency improvement in Germany [PDF]
The paper presents results of the implementation of an efficiency strategy in Germany until 2020 which is focused on cost-effective measures. The efficiency measures are calculated in bottom-up models and translated into a top-down macro-economic model ...
Barbara Schlomann +7 more
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Bottom-up and top-down neuromorphic processor design : Unveiling roads to embedded cognition
, 2020 While Moore's law has driven exponential computing power expectations, its nearing end calls for new roads to embedded cognition. The field of neuromorphic computing aims at a two-fold paradigm shift compared to conventional computing. First, it investigates the co-location of processing and memory in neurons and synapses.
openaire +1 more source
Integrating top-down and bottom-up approaches to design a cost-effective and equitable programme of measures for adaptation of a river basin to global change. [PDF]
, 2016 [CA] L'adaptació als múltiples aspectes del canvi global implica un repte per als enfocaments convencionals de planificació i gestió sostenible dels recursos hídrics a escala de conca. Existeixen nombroses opcions de gestió de la demanda y de la oferta.
openaire +4 more sources