Results 121 to 130 of about 4,098,484 (351)

TRPM4 contributes to cell death in prostate cancer tumor spheroids, and to extravasation and metastasis in a zebrafish xenograft model system

Molecular Oncology, Volume 19, Issue 5, Page 1299-1309, May 2025.
Transient receptor potential melastatin‐4 (TRPM4) is overexpressed in prostate cancer (PCa). Knockout of TRPM4 resulted in reduced PCa tumor spheroid size and decreased PCa tumor spheroid outgrowth. In addition, lack of TRPM4 increased cell death in PCa tumor spheroids.
Florian Bochen, Saurav Subedi, Federico La Manna, Sofia Jarrin, Irida Papapostolou, Marianna Kruithof‐de Julio, Christine Peinelt   +6 more
wiley   +1 more source

Cystatin A promotes the antitumor activity of T helper type 1 cells and dendritic cells in murine models of pancreatic cancer

Molecular Oncology, Volume 19, Issue 5, Page 1452-1470, May 2025.
Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti, Shingo Inagaki, Tuyen Thuy Bich Ho, Akihiro Seki, Keiko Yoshida, Kosuke Satomura, Yoshio Sakai, Shuichi Kaneko, Taro Yamashita   +8 more
wiley   +1 more source

Top down, bottom up structured programming and program structuring [PDF]

New design and programming techniques for shuttle software. Based on previous Apollo experience, recommendations are made to apply top-down structured programming techniques to shuttle software.
Hamilton, M., Zeldin, S.
core   +1 more source

From lists of behaviour change techniques (BCTs) to structured hierarchies: comparison of two methods of developing a hierarchy of BCTs [PDF]

, 2014
Objectives Behaviour change technique (BCT) Taxonomy v1 is a hierarchically grouped, consensus-based taxonomy of 93 BCTs for reporting intervention content.
Abraham, Abraham, Amemori, Araújo-Soares, Baddley, Beenstock, Boutron, Bussières, Cane, Carmines, Chadwick, Craig, Davies, Dixon, Dixon, Dombrowski, Dyson, Francis, Francis, Free, French, Geller, Hardeman, Hobbs, Hochberg, Ivers, Lorencatto, Lynn, McKenzie, McKenzie, Michie, Michie, Michie, Michie, Michie, Michie, Michie, Michie, Michie, Michie, Michie, Mokdad, Parkin, Patey, Polyn, R Development Core Team, Taylor, Tulving, Waltz, Webb, West   +50 more
core   +3 more sources

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

Molecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia, Anouk C. de Jong, Lisanne F. van Dessel, Vanja de Weerd, Corine Beaufort, Jean Helmijr, José Alberto Nakauma‐González, Job van Riet, Paul Hamberg, Daniel Vis, Michiel S. van der Heijden, Nick Beije, Martijn P. Lolkema, Teoman Deger, Saskia M. Wilting, Ronald de Wit, Maurice P. H. M. Jansen, John W. M. Martens   +17 more
wiley   +1 more source

An Evaluation Methodology Development and Application Process for Severe Accident Safety Issue Resolution

Science and Technology of Nuclear Installations, 2012
A general evaluation methodology development and application process (EMDAP) paradigm is described for the resolution of severe accident safety issues.
Robert P. Martin
doaj   +1 more source

Sliced rotated sphere packing designs [PDF]

arXiv, 2017
Space-filling designs are popular choices for computer experiments. A sliced design is a design that can be partitioned into several subdesigns. We propose a new type of sliced space-filling design called sliced rotated sphere packing designs. Their full designs and subdesigns are rotated sphere packing designs.
arxiv  

Evaluating practitioner cyber-security attack graph configuration preferences [PDF]

, 2018
Attack graphs and attack trees are a popular method of mathematically and visually rep- resenting the sequence of events that lead to a successful cyber-attack.
Bal, Jay, Debattista, Kurt, Lallie, Harjinder Singh   +2 more
core   +1 more source

CRISPR targeting of FOXL2 c.402C>G mutation reduces malignant phenotype in granulosa tumor cells and identifies anti‐tumoral compounds

Molecular Oncology, Volume 19, Issue 4, Page 1092-1116, April 2025.
FOXL2 c.402C>G mutation drives granulosa cell tumors. Using CRISPR technology, we selectively corrected this mutation, reducing malignancy and increasing sensitivity to dasatinib and ketoconazole. Transcriptomic changes revealed potential therapeutic targets, demonstrating CRISPR's promise for treating this rare ovarian cancer.
Sandra Amarilla‐Quintana, Paloma Navarro, Iván Hernández, Alejandra Ramos, Ana Montero‐Calle, Pablo Cabezas‐Sainz, Maria J Barrero, Diego Megías, Borja Vilaplana‐Martí, Carolina Epifano, Déborah Gómez‐Dominguez, Sara Monzón, Isabel Cuesta, Laura Sánchez, Rodrigo Barderas, Jesús García‐Donas, Alberto Martín, Ignacio Pérez de Castro   +17 more
wiley   +1 more source

Complex System Design with Design Languages: Method, Applications and Design Principles [PDF]

arXiv, 2018
Graph-based design languages in UML (Unified Modeling Language) are presented as a method to encode and automate the complete design process and the final optimization of the product or complex system. A design language consists of a vocabulary (digital building blocks) and a set of rules (digital composition knowledge) along with an executable ...
arxiv