Results 131 to 140 of about 1,624,943 (326)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Paradigm shift from self-assembly to commanded assembly of functional materials: recent examples in porphyrin/fullerene supramolecular systems

Science and Technology of Advanced Materials, 2012
Current nanotechnology based on top-down nanofabrication may encounter a variety of drawbacks in the near future so that development of alternative methods, including the so-called bottom-up approach, has attracted considerable attention.
Mao Li, Shinsuke Ishihara, Qingmin Ji, Misaho Akada, Jonathan P Hill and Katsuhiko Ariga
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

From top-down to people-centred urban recovery: a Beirut case study

Miscellanea Geographica: Regional Studies on Development
Urban recovery which follows structural devastation presents a multitude of challenges. While top-down recovery approaches are relatively common, there is a growing emphasis on people-centred design, which prioritises the needs and visions of the primary
Verešová Dominika
doaj   +1 more source

Peranan Pengambil Kebijakan dalam Pengembangan Masyarakat [PDF]

, 2010
System of government in Indonesia that has been changed from centralized (top-down) to decentralized (bottom-up)or autonomous regions (Regional Autonomy) is marked based on the Law No. 22/1999 on Regional Government,which was revised by Law No.
Hubeis, M. (M)
core  

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Style-Based architectural reconfigurations [PDF]

, 2007
We introduce Architectural Design Rewriting (ADR), an approach to the design of reconfigurable software architectures whose key features are: (i) rule-based approach (over graphs); (ii) hierarchical design; (iii) algebraic presentation; and (iv ...
Bruni, Roberto, Lluch-Lafuente, Alberto, Montanari, Ugo, Tuosto, Emilio   +3 more
core  

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Multi-Scale Face Restoration with Sequential Gating Ensemble Network

, 2018
Restoring face images from distortions is important in face recognition applications and is challenged by multiple scale issues, which is still not well-solved in research area.
Chen, Zhibo, Lin, Jianxin, Zhou, Tiankuang   +2 more
core   +1 more source

Fig. S1 The experimental design.; Fig. S2 Vegetation in the small-scale experiments in August 2014.; Fig. S3 Microclimates in the both large- and small-scale experiments in August 2014.; Fig. S4 Vegetation in the large-scale experiments in August 2012. from Ecosystem engineering strengthens bottom-up and weakens top-down effects via trait-mediated indirect interactions

, 2017
The experimental design for this study in a semi-arid low elevation grassland in Jilin Province in northern China.; Effects of sheep grazing and forb removal on plant community structure in the microcosm experiments in August 2014.; Microclimates in the both large- and small-scale experiments in August 2014.; Effects of sheep grazing (control versus ...
Zhong, Zhiwei, Li, Xiaofei, Pearson, Dean, Wang, Deli, Sanders, Dirk, Zhu, Yu, Wang, Ling   +6 more
openaire   +1 more source