Results 141 to 150 of about 4,098,484 (351)
Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance
Molecular Oncology, EarlyView.Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren +4 more
wiley +1 more source
Integrated sleep scheduling for multiple relays and UEs in LTE-TDD
EURASIP Journal on Wireless Communications and Networking, 2019 Energy-saving for the LTE-A network with relay nodes in TDD mode is addressed in this paper, and integrated sleep scheduling schemes for relay nodes and user devices under a base station are designed.
Chun-Chuan Yang +3 more
doaj +1 more source
Bottom-up vs. top-down: how participatory design can be used to help define post-conflict cultural memory in Croatia [PDF]
, 2023 Antonia Jolic
openalex +1 more source
Pro-Active Regional Development Policy - the Croatian Case [PDF]
The paper deals with existing regional development discrepancies in Croatia and discusses possibilities of initiating dormant development potentials and closing development gaps. Bottom up policy approach is analysed in view of Croatian specific regional
Marijana Sumpor, Nenad Starc
core
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Science and Technology of Advanced Materials, 2012 Current nanotechnology based on top-down nanofabrication may encounter a variety of drawbacks in the near future so that development of alternative methods, including the so-called bottom-up approach, has attracted considerable attention.
Mao Li, Shinsuke Ishihara, Qingmin Ji, Misaho Akada, Jonathan P Hill and Katsuhiko Ariga
doaj +1 more source
CHIMIA, 2010 Single molecule electronics is a field of research focused on the use of single molecules as electronics components. During the past 15 years the field has concentrated on development of test beds for measurements on single molecules.
Kasper Moth-Poulsen, Thomas Bjørnholm
doaj +1 more source
Rediscovering Bottom-Up: Effective Forecasting in Temporal Hierarchies [PDF]
arXivForecast reconciliation has become a prominent topic in recent forecasting literature, with a primary distinction made between cross-sectional and temporal hierarchies. This work focuses on temporal hierarchies, such as aggregating monthly time series data to annual data.
arxiv
Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer
Molecular Oncology, EarlyView.We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi +26 more
wiley +1 more source
Both Generic Design and Different Forms of Designing [PDF]
Dans Wonderground, the 2006 DRS (Design Research Society)
International Conference (2006), 2006 This paper defends an augmented cognitively oriented "generic-design hypothesis": There are both significant similarities between the design activities implemented in different situations and crucial differences between these and other cognitive activities; yet, characteristics of a design situation (i.e., related to the designers, the artefact, and ...
arxiv