Results 161 to 170 of about 4,098,484 (351)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Conceptual Design and Parametric Optimization of a New Multileveled Horsetail Structure for Bicycle Helmets

Advanced Engineering Materials, EarlyView., 2023
This study aims to explore the feasibility of using a structure inspired by the features of horsetail and human spine as the potential helmet liner, targeting at mitigation of acceleration‐induced injuries. A parametric study is conducted to investigate the effect of individual geometrical variables in the design, indicating its capability to reduce ...
Bing Leng, Dong Ruan, Shanqing Xu, Kwong Ming Tse   +3 more
wiley   +1 more source

Structural synthesis of parallel programs (Methodology and Tools) [PDF]

Computer Science Journal of Moldova, 1995
Concepts of structured programming and propositional program logics were anticipated in the systems of algorithmic algebras (SAAs) introduced by V.M.Glushkov in 1965.
G. Cejtlin, E. Jushchenko
doaj  

Top-down and bottom-up: Studying the SMEFT beyond leading order in $1/Λ^2$ [PDF]

arXiv
In order to assess the relevance of higher order terms in the Standard Model Effective Field Theory (SMEFT) expansion we consider four new physics models and their impact on the Drell Yan cross section. Of these four, one scalar model has no effect on Drell Yan, a model of fermions while appearing to generate a momentum expansion actually belongs to ...
arxiv  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Flexural Behavior of Bidirectionally Graded Lattice

Advanced Engineering Materials, EarlyView., 2023
An experimental study of the bending behavior of bidirectional body‐centered cubic lattice beams is conducted in comparison to uniform and unidirectional counterparts of electron beam melted SS 316 L. Experimental results are used to develop and validate a finite element model which is subsequently used to conduct parametric studies to assess the ...
Chamini Rodrigo, Shanqing Xu, Yvonne Durandet, Darren Fraser, Dong Ruan   +4 more
wiley   +1 more source

An empirical resource for discovering cognitive principles of discourse organisation: the ANNODIS corpus [PDF]

, 2012
International audienceThis paper describes the ANNODIS resource, a discourse-level annotated corpus for French. The corpus combines two perspectives on discourse: a bottom-up approach and a top-down approach.
Afantenos, Stergos, Asher, Nicholas, Benamara, Farah, Bras, Myriam, Fabre, Cécile, Ho-Dac, Lydia-Mai, Le Draoulec, Anne, Muller, Philippe, Prevot, Laurent, Péry-Woodley, Marie-Paule, Rebeyrolle, Josette, Tanguy, Ludovic, Vergez-Couret, Marianne, Vieu, Laure   +13 more
core   +3 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Topology Optimization of Lattice Support Structure for Cantilever Beams Fabricated Via Laser Powder Bed Fusion

Advanced Engineering Materials, EarlyView., 2023
A numerical scheme is presented to design a lattice support for metallic components additively built via laser powder bed fusion. Results show that thermal‐induced distortion can be respectively reduced by 69%, 58%, and 50% in comparison to a uniform lattice, a fully solid support, and a truss‐based lattice support.
Jiazheng Hu, Marjan Molavi‐Zarandi, Damiano Pasini   +2 more
wiley   +1 more source

Top-Down or Bottom-Up Data Model Design: Which is Best?

AbstractWhen designing an effective enterprise data strategy, organizations often choose between a top-down and a bottom-up approach. Each method has its unique advantages and is suitable for various scenarios. The top-down approach begins with a high-level view of the business needs and strategic objectives, then gradually breaks down this view into ...
openaire   +1 more source