Results 61 to 70 of about 1,538,506 (330)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Reflecting on the usability of research on culture in designing interaction [PDF]

, 2010
The concept of culture has been attractive to producers of interactive\ud systems who are willing to design useful and relevant solutions to users\ud increasingly located in culturally diverse contexts.
Camara, Souleymane, Nocera, Jose L. Abdelnour   +1 more
core   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Re‐considering and designing microbiomes for future waste biorefinery

Microbial Biotechnology
It is an increasingly promising research direction using microbiomes to produce various chemicals in order to support people's growing need for sustainability.
Menghan Wu, Hui Wang
doaj   +1 more source

From emissions to source allocation: Synergies and trade-offs between top-down and bottom-up information

Atmospheric Environment: X, 2020
This study investigates the dispersion of atmospheric pollutants over a coastal region of north-western Italy by means of modelling techniques. A series of annual air quality model simulations corresponding to different emission reduction scenarios has ...
L. Sartini, Marta Antonelli, E. Pisoni, P. Thunis   +3 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Choosing the Right Construction Method: A Comparative Study of Cost and Timeline for Top-Down and Bottom-Up Approaches

Buildings
The selection of an appropriate construction method stands as a pivotal decision in ensuring the success of any building project. This paper undertakes a comprehensive comparative analysis of cost and timeline implications between the top-down and bottom-
Çetin Meral, Bayram Ali Temel, Hasan Basri Başaga   +2 more
doaj   +1 more source

CO2 coordination-driven top-down synthesis of a 2D non-layered metal–organic framework

Fundamental Research, 2022
Combining the physical advantages of two-dimensional (2D) inorganic nanosheets and the modular design and programmed structure of metal-organic frameworks (MOFs), 2D MOFs remain at the forefront of functional material research. Despite tremendous efforts,
Yannan Zhou, Pengfei Yan, Suoying Zhang, Yunxiao Zhang, Hongwei Chang, Xiaoli Zheng, Jingyun Jiang, Qun Xu   +7 more
doaj   +1 more source

A "Social Bitcoin" could sustain a democratic digital world [PDF]

, 2016
A multidimensional financial system could provide benefits for individuals, companies, and states. Instead of top-down control, which is destined to eventually fail in a hyperconnected world, a bottom-up creation of value can unleash creative potential ...
Helbing, Dirk, Kleineberg, Kaj-Kolja
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source