Results 61 to 70 of about 4,098,484 (351)

Effect of design factors on drivers’ understanding of variable message signs locating traffic events [PDF]

, 2022
Background: This article addresses how to combine three elements (a pictogram, an arrow, a city) in a variable message sign (VMS) to locate temporary events (e.g., “congestion before Milan”).
Blanch Micó, M. T., Hernando Mazón, A., Lombas, A. S., Lucas Alba, A.   +3 more
core   +1 more source

Insights into the renal pathophysiology in Hermansky‐Pudlak syndrome‐1 from urinary extracellular vesicle proteomics and a new mouse model

FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.
Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard, Bernadette R. Gochuico, Hadass Pri Chen, Christopher K. E. Bleck, Patricia M. Zerfas, Wendy J. Introne, William A. Gahl, May C. V. Malicdan   +7 more
wiley   +1 more source

G-optimal grid designs for kriging models [PDF]

arXiv, 2021
This work is focused on finding G-optimal designs theoretically for kriging models with two-dimensional inputs and separable exponential covariance structures. For design comparison, the notion of evenness of two-dimensional grid designs is developed. The mathematical relationship between the design and the supremum of the mean squared prediction error
arxiv  

Cytosolic‐enhanced dark Epac‐based FRET sensors allow for intracellular cAMP detection in live cells via FLIM

FEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.
We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti, Jeffrey B. Klarenbeek, Kees Jalink   +2 more
wiley   +1 more source

Bottom-up or top-down: unit cost estimation of tuberculosis diagnostic tests in India. [PDF]

, 2017
SETTING: Of 18 sites that participated in an implementation study of the Xpert® MTB/RIF assay in India, we selected five microscopy centres and two reference laboratories. OBJECTIVE: To obtain unit costs of diagnostic tests for tuberculosis (TB) and drug-
Boehme, C, Hoog, AH Van't, Khaparde, SD, Nair, SA, Raizada, N, Rupert, S, Sachdeva, KS, Salhotra, VS, Vassall, A   +8 more
core   +1 more source

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

FEBS Letters, Volume 599, Issue 9, Page 1260-1268, May 2025.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr, Klaus Mayer, Raffael Schaffrath, Johannes Buchner, Ulrich Brinkmann   +4 more
wiley   +1 more source

Re‐considering and designing microbiomes for future waste biorefinery

Microbial Biotechnology
It is an increasingly promising research direction using microbiomes to produce various chemicals in order to support people's growing need for sustainability.
Menghan Wu, Hui Wang
doaj   +1 more source

Choosing the Right Construction Method: A Comparative Study of Cost and Timeline for Top-Down and Bottom-Up Approaches

Buildings
The selection of an appropriate construction method stands as a pivotal decision in ensuring the success of any building project. This paper undertakes a comprehensive comparative analysis of cost and timeline implications between the top-down and bottom-
Çetin Meral, Bayram Ali Temel, Hasan Basri Başaga   +2 more
doaj   +1 more source

Reflecting on the usability of research on culture in designing interaction [PDF]

, 2010
The concept of culture has been attractive to producers of interactive\ud systems who are willing to design useful and relevant solutions to users\ud increasingly located in culturally diverse contexts.
Camara, Souleymane, Nocera, Jose L. Abdelnour   +1 more
core   +1 more source

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

FEBS Letters, Volume 599, Issue 8, Page 1146-1158, April 2025.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka, Takahiro Ogawa, Rikako Tsukida, Keiichi Noguchi, David Hibbett, Yoko Katayama, Makoto Yoshida   +6 more
wiley   +1 more source