Results 71 to 80 of about 4,098,484 (351)
Ecology of Caribbean sponges: are top-down or bottom-up processes more important? [PDF]
PLoS ONE, 2013 Benthic-pelagic coupling and the role of bottom-up versus top-down processes are recognized as having a major impact on the structure of marine communities.
Michael P Lesser, Marc Slattery
doaj +1 more source
FEBS Letters, EarlyView.Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung +6 more
wiley +1 more source
Constraining biospheric carbon dioxide fluxes by combined top-down and bottom-up approaches [PDF]
Atmospheric Chemistry and PhysicsWhile the growth rate of atmospheric CO2 mole fractions can be measured with high accuracy, there are still large uncertainties in its attribution to specific regions and diverse anthropogenic and natural sources and sinks.
S. Upton +7 more
doaj +1 more source
IEEE Access, 2023 This paper proposed an innovative method for aesthetic education by integrating shape grammar and neuroaesthetics. Aesthetic education can be divided into bottom-up aesthetic cultivation and top-down knowledge education, which correspond to the ...
Shaoting Zeng, Xin Lyu, Jingfan Kang
doaj +1 more source
Project Risk Management from the bottom-up: Activity Risk Index [PDF]
Cent Eur J Oper Res 29, 1375-1396 (2021)Project managers need to manage risks throughout the project lifecycle and, thus, need to know how changes in activity durations influence project duration and risk. We propose a new indicator (the Activity Risk Index, ARI) that measures the contribution of each activity to the total project risk while it is underway.
arxiv +1 more source
BOgen: Generating Part-Level 3D Designs Based on User Intention Inference through Bayesian Optimization and Variational Autoencoder [PDF]
arXiv, 2023 Advancements in generative artificial intelligence (AI) have introduced various AI models capable of producing impressive visual design outputs. However, when it comes to AI models in the design process, prioritizing outputs that align with designers' needs over mere visual craftsmanship becomes even more crucial.
arxiv
Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases
FEBS Letters, Volume 599, Issue 8, Page 1094-1112, April 2025.The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher +6 more
wiley +1 more source
An evaluation of the current urban design process in order to derive critical success factors for the creation of a potential new urban design process framework [PDF]
, 2015 The current urban design process is top-down, i.e., generally the urban designers or planners design the urban environment and at a later stage the community may have some involvement. There are serious criticisms of this process as it may not touch the “
Amaratunga, Dilanthi +3 more
core
Networks of silicon nanowires: a large-scale atomistic electronic structure analysis [PDF]
, 2013 Networks of silicon nanowires possess intriguing electronic properties surpassing the predictions based on quantum confinement of individual nanowires.
Bulutay, Ceyhun +3 more
core +2 more sources
FEBS Letters, Volume 599, Issue 7, Page 1006-1028, April 2025.This study explores the distinct molecular mechanisms underlying Lynch syndrome‐associated and sporadic colorectal cancer (CRC). By highlighting the therapeutic potential of targeting the PI3K‐Akt pathway in Lynch syndrome‐associated CRC and the Wnt pathway in sporadic CRC, the findings open avenues for personalised treatment strategies, aiming to ...
May J. Krause +2 more
wiley +1 more source