Results 71 to 80 of about 1,548,118 (340)
Ecology of Caribbean sponges: are top-down or bottom-up processes more important? [PDF]
PLoS ONE, 2013 Benthic-pelagic coupling and the role of bottom-up versus top-down processes are recognized as having a major impact on the structure of marine communities.
Michael P Lesser, Marc Slattery
doaj +1 more source
Renewal of Buenos Aires city waterfront [PDF]
, 2010 This paper reports an analysis of the main phases and factors relevant to the renovation of the coastal area of the city of Buenos Aires. Since the early 1980s, and especially with the country's comeback of democratic life, that area developed along two ...
Faggi, Ana Maria
core +1 more source
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Constraining biospheric carbon dioxide fluxes by combined top-down and bottom-up approaches [PDF]
Atmospheric Chemistry and PhysicsWhile the growth rate of atmospheric CO2 mole fractions can be measured with high accuracy, there are still large uncertainties in its attribution to specific regions and diverse anthropogenic and natural sources and sinks.
S. Upton +7 more
doaj +1 more source
IEEE Access, 2023 This paper proposed an innovative method for aesthetic education by integrating shape grammar and neuroaesthetics. Aesthetic education can be divided into bottom-up aesthetic cultivation and top-down knowledge education, which correspond to the ...
Shaoting Zeng, Xin Lyu, Jingfan Kang
doaj +1 more source
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
wiley +1 more source
A "Social Bitcoin" could sustain a democratic digital world [PDF]
, 2016 A multidimensional financial system could provide benefits for individuals, companies, and states. Instead of top-down control, which is destined to eventually fail in a hyperconnected world, a bottom-up creation of value can unleash creative potential ...
Helbing, Dirk, Kleineberg, Kaj-Kolja
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Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
An evaluation of the current urban design process in order to derive critical success factors for the creation of a potential new urban design process framework [PDF]
, 2015 The current urban design process is top-down, i.e., generally the urban designers or planners design the urban environment and at a later stage the community may have some involvement. There are serious criticisms of this process as it may not touch the “
Amaratunga, Dilanthi +3 more
core
Molecular Oncology, EarlyView.We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau +11 more
wiley +1 more source