Results 81 to 90 of about 4,098,484 (351)
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source
Understanding and Supporting the Design Systems Practice [PDF]
arXiv, 2022 Design systems represent a user interaction design and development approach that is currently of avid interest in the industry. However, little research work has been done to synthesize knowledge related to design systems in order to inform the design of tools to support their creation, maintenance, and usage practices.
arxiv
Augmenting Bottom-Up Metamodels with Predicates [PDF]
, 2017 Metamodeling refers to modeling a model. There are two metamodeling approaches for ABMs: (1) top-down and (2) bottom-up. The top down approach enables users to decompose high-level mental models into behaviors and interactions of agents. In contrast, the
Diallo, Saikou +3 more
core +2 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Deep Generative Design: Integration of Topology Optimization and Generative Models [PDF]
Journal of Mechanical Design, 141(11), 111405, 2019 Deep learning has recently been applied to various research areas of design optimization. This study presents the need and effectiveness of adopting deep learning for generative design (or design exploration) research area. This work proposes an artificial intelligent (AI)-based design automation framework that is capable of generating numerous design ...
arxiv +1 more source
, 2021 While Moore's law has driven exponential computing power expectations, its nearing end calls for new avenues for improving the overall system performance. One of these avenues is the exploration of new alternative brain-inspired computing architectures that promise to achieve the flexibility and computational efficiency of biological neural processing ...
Frenkel, Charlotte Philippine +2 more
openaire +2 more sources
Social context prevents heat hormetic effects against mutagens during fish development
FEBS Letters, EarlyView.This study shows that sublethal heat stress protects fish embryos against ultraviolet radiation, a concept known as ‘hormesis’. However, chemical stress transmission between fish embryos negates this protective effect. By providing evidence for the mechanistic molecular basis of heat stress hormesis and interindividual stress communication, this study ...
Lauric Feugere +5 more
wiley +1 more source
Research for All, 2022 To better address twenty-first-century challenges, research institutions often develop and publish research impact strategies, but as a tool, impact strategies are poorly understood.
doaj +2 more sources
Bottom-Up Design Approach for OBOC Peptide Libraries
Molecules, 2020 One-bead-one-compound peptide libraries, developed following the top-down experimental approach, have attracted great interest in the identification of potential ligands or active peptides.
Daniela Kalafatovic +3 more
doaj +1 more source
arXiv, 2019 Lecture Notes for Les Houches 2018 Summer School on Active Matter and Nonequilibrium Statistical Physics. These notes give an introduction to statistical field theories of active matter. After showing an example of how such theories can be created bottom-up by explicit coarse graining of active particle models, the main approach taken here is top-down:
arxiv