The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity
FEBS Letters, EarlyView.The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley +1 more source
Evaluating practitioner cyber-security attack graph configuration preferences [PDF]
, 2018 Attack graphs and attack trees are a popular method of mathematically and visually rep- resenting the sequence of events that lead to a successful cyber-attack.
Bal, Jay +2 more
core +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
An empirical resource for discovering cognitive principles of discourse organisation: the ANNODIS corpus [PDF]
, 2012 International audienceThis paper describes the ANNODIS resource, a discourse-level annotated corpus for French. The corpus combines two perspectives on discourse: a bottom-up approach and a top-down approach.
Afantenos, Stergos +13 more
core +3 more sources
Decentralized provenance-aware publishing with nanopublications [PDF]
, 2016 Publication and archival of scientific results is still commonly considered the responsability of classical publishing companies. Classical forms of publishing, however, which center around printed narrative articles, no longer seem well-suited in the ...
Chichester, Christine +8 more
core +4 more sources
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Research for All, 2022 To better address twenty-first-century challenges, research institutions often develop and publish research impact strategies, but as a tool, impact strategies are poorly understood.
doaj +2 more sources
Bottom-Up Design Approach for OBOC Peptide Libraries
Molecules, 2020 One-bead-one-compound peptide libraries, developed following the top-down experimental approach, have attracted great interest in the identification of potential ligands or active peptides.
Daniela Kalafatovic +3 more
doaj +1 more source
Bottom-up and top-down approaches for the design of neuromorphic processing systems: Tradeoffs and synergies between natural and artificial intelligence [PDF]
, 2021 Charlotte Frenkel +2 more
openalex +1 more source