Results 101 to 110 of about 76,577 (242)

Development of an Integrated Computational Pipeline for PARP‐1 Inhibitor Screening Using Hybrid Virtual Screening and Molecular Dynamics Simulations

open access: yesChemistryOpen, EarlyView.
Poly(ADP‐ribose) polymerase 1 (PARP‐1) is vital for DNA repair. A computational workflow integrating AI‐driven virtual screening (TransFoxMol, KarmaDock, AutoDock Vina) and molecular dynamics identified novel PARP‐1 inhibitors with promising efficacy and minimized side effects.
Guan Wang   +3 more
wiley   +1 more source

Landscape transcriptomics as a tool for addressing global change effects across diverse species

open access: yesMolecular Ecology Resources, EarlyView., 2023
Abstract Landscape transcriptomics is an emerging field studying how genome‐wide expression patterns reflect dynamic landscape‐scale environmental drivers, including habitat, weather, climate, and contaminants, and the subsequent effects on organismal function. This field is benefitting from advancing and increasingly accessible molecular technologies,
Jason Keagy   +9 more
wiley   +1 more source

Are public housing projects good for kids after all?

open access: yesJournal of Policy Analysis and Management, EarlyView.
Abstract Is public housing bad for children? The net effect of moving into public housing on children's academic outcomes is theoretically ambiguous and likely to depend on changes to neighborhood and school characteristics. Drawing on detailed individual‐level longitudinal data on New York City public school students, we exploit plausibly random ...
Jeehee Han, Amy Ellen Schwartz
wiley   +1 more source

Applicability Assessment of Technologies for Predictive and Prescriptive Analytics of Nephrology Big Data

open access: yesPROTEOMICS, EarlyView.
ABSTRACT The integration of big data into nephrology research will open new avenues for analyzing and understanding complex biological datasets, driving advances in personalized management of kidney diseases. This paper describes the multifaceted challenges and opportunities by incorporating big data in nephrology, emphasizing the importance of data ...
Riste Stojanov   +12 more
wiley   +1 more source

Fecal Metaproteomics as a Tool to Monitor Functional Modifications Induced in the Gut Microbiota by Ketogenic Diet: A Case Study

open access: yesPROTEOMICS, EarlyView.
ABSTRACT Metaproteomics is a valuable approach to characterize the biological functions involved in the gut microbiota (GM) response to dietary interventions. Ketogenic diets (KDs) are very effective in controlling seizure severity and frequency in drug‐resistant epilepsy (DRE) and in the weight loss management in obese/overweight individuals.
Alessandro Tanca   +3 more
wiley   +1 more source

Assessing Structural Classification Using AlphaFold2 Models Through ECOD‐Based Comparative Analysis

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Identifying homologous proteins is a fundamental task in structural bioinformatics. While AlphaFold2 has revolutionized protein structure prediction, the extent to which structure comparison of its models can reliably detect homologs remains unclear.
Takeshi Kawabata, Kengo Kinoshita
wiley   +1 more source

Phosphorylation Changes SARS‐CoV‐2 Nucleocapsid Protein's Structural Dynamics and Its Interaction With RNA

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The SARS‐CoV‐2 nucleocapsid protein, or N‐protein, is a structural protein that plays an important role in the SARS‐CoV‐2 life cycle. The N‐protein takes part in the regulation of viral RNA replication and drives highly specific packaging of full‐length genomic RNA prior to virion formation.
Stefan Loonen   +3 more
wiley   +1 more source

Using AlphaFold and Symmetrical Docking to Predict Protein–Protein Interactions for Exploring Potential Crystallization Conditions

open access: yesProteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Protein crystallization remains a major bottleneck in X‐ray crystallography due to difficulties in achieving favorable molecular arrangements within the crystal lattice. While protein–protein interactions at molecular packing interfaces are crucial for determining crystallization conditions, methods for predicting crystal packing interfaces ...
Kuan‐Ju Liao, Yuh‐Ju Sun
wiley   +1 more source

‘Attitude Problems’: Racializing Hierarchies of Affect in Post‐Brown U.S. Science Education

open access: yesScience Education, EarlyView.
ABSTRACT Attending to the affect of minoritized students now appears crucial to promoting just and dignity‐affirming science education. Yet, elevating affect as an objective of science learning has a history that predates equity reforms. This study explores the politics of scientific uptakes of affect that have long served to mark hierarchical ...
Kathryn L. Kirchgasler
wiley   +1 more source

Uncovering Emotion in Youth Digital Civic Participation Around Climate Change: Entanglements of Fear, Despair, and Anger in Civic Practice

open access: yesScience Education, EarlyView.
ABSTRACT Attention to emotion could offer insight into supporting the science‐informed civic participation of young people. We drew on sociocultural views of emotion, civic participation, and science literacies to examine digital civic media about climate change produced by youth during the 2020 U.S.
Lynne Zummo, Lea Hadzic, Emma Gargroetzi
wiley   +1 more source

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