Results 101 to 110 of about 29,782 (235)
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
reservedThis thesis explores the strategic role and involvement of Middle Managers (MM) in fostering innovation within managerial and family-owned manufacturing companies in Italy.
TALLON, GIULIA
core
Understanding the work of top managers : a shadowing study of Canadian healthcare CEOs [PDF]
This thesis investigates three research questions about the nature of managerial work: (1) What do we know about the nature of managerial work?; (2) To what extent is the work of top managers in the public and private sectors different?; and (3) What ...
Johnson, Bart Morley
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Towards the adoption of new management methods in a modernising national business system?: a study of the responses of middle managers to Total Quality Management in Greek service industry [PDF]
Total Quality Management (TQM) emerged as a promising management practice mainly in the US and the UK. Its principles challenge the managerial traditions of other countries. A prime example is Greece.
Psychogios, Alexandros G.
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
BMC Public HealthBackground There is a growing awareness for addressing mental health in the workplace. Although interventions to promote mental health at the organizational-level exist, implementation is a challenge.
Lily Joanne Anzion +4 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Jurnal Manajemen Dan Kewirausahaan, 2017 This research analyzes the influence of the various dimensions of quality on the company performance. The source of data research are 75 companies composed of 46 major companies and 29 medium companies. The data collected through middle managers and ...
Syaiful Arifin, Tri Wahyuni
doaj